ZFIN ID: ZDB-GENE-050327-78
Gene Name: alkaline phosphatase, intestinal, tandem duplicate 1
Gene Symbol: alpi.1    Nomenclature History

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Previous Names: alpi (1), iap (1), im:7149588, si:ch211-262h13.1 (1), wu:fa95f04, zgc:110794 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 22 Mapping Details/Browsers
Description: Predicted to have alkaline phosphatase activity. Human ortholog(s) of this gene implicated in inflammatory bowel disease. Is expressed in several structures, including floor plate; intestine; median fin fold; periderm; and segmental plate. Orthologous to human ALPI (alkaline phosphatase, intestinal).
Genome Resources: Alliance (1),  Gene:541539 (1),  Ensembl(GRCz11):ENSDARG00000015273 (2)
GENE EXPRESSION
All Expression Data: 10 figures from 4 publications
Directly Submitted Expression Data: 6 figures (9 images) from Thisse et al., 2004 [IMAGE:7149588]
Wild-type Stages, Structures: Segmentation:1-4 somites (10.33h-11.66h) to Larval:Days 7-13 (168.0h-14d, 4.5mm, 8 teeth)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa32416 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-alpi.1 N/A 2
    PHENOTYPE
    Data: 2 figures from Bates et al., 2007
    Observed in:
    DISEASE ASSOCIATED WITH alpi.1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH alpi.1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process dephosphorylation (more)
    Cellular Component plasma membrane (more)
    Molecular Function alkaline phosphatase activity (more)
    GO Terms (all 6)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Family IPR001952 Alkaline phosphatase
    Homologous_superfamily IPR017850 Alkaline-phosphatase-like, core domain superfamily
    Active_site IPR018299 Alkaline phosphatase, active site
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA alpi.1-203 (1)    Ensembl 808
    alpi.1-204 (1)    Ensembl 1871
    ncRNA alpi.1-003 (1) 785
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM alpi.1 No data available
    MARKER RELATIONSHIPS
    alpi.1 Contained in: [BAC] CH211-262H13 (1)
    alpi.1 Encodes: [EST] fa95f04 (1), IMAGE:7149588 (1)
    [cDNA] MGC:110794 (1), MGC:193081 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001014353 (1) 1970 bp
    Genomic GenBank:BX927181 (1) 68264 bp
    Select Tool
    Polypeptide UniProtKB:F1QAR9 (1) 532 aa
    Sequence Information (all 24)
    ORTHOLOGY for alpi.1 ( Chr: 22 )
    CITATIONS (31)