ZFIN ID: ZDB-GENE-050327-68
Gene Name: inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
Gene Symbol: ikbkg    Nomenclature History

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Previous Names: ikky (1), fj33c07, nemo (1), wu:fj33c07, zgc:113492

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 23 Mapping Details/Browsers
Description: Predicted to have K63-linked polyubiquitin modification-dependent protein binding activity. Involved in I-kappaB phosphorylation and positive regulation of I-kappaB kinase/NF-kappaB signaling. Predicted to localize to IkappaB kinase complex and nucleus. Is expressed in periderm. Human ortholog(s) of this gene implicated in Behcet's disease; Bloch-Sulzberger syndrome; hypohidrotic ectodermal dysplasia; learning disability; and primary immunodeficiency disease. Orthologous to human IKBKG (inhibitor of nuclear factor kappa B kinase regulatory subunit gamma).
Genome Resources: Alliance (1),  Gene:541530 (1),  Ensembl(GRCz11):ENSDARG00000017037 (2)
GENE EXPRESSION
All Expression Data: 8 figures from 3 publications
Directly Submitted Expression Data: 6 figures (2 images) from Thisse et al., 2004 [IMAGE:7147563]
Wild-type Stages, Structures: Gastrula:75%-epiboly (8.0h-9.0h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
c220Gt Transgenic Insertion Unknown Unknown DNA
s838 Unknown Unknown Unknown ENU
sa24293 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa29899 Point Mutation Unknown Premature Stop ENU
    sa44998 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • PHENOTYPE
    Data: Fig. S2 from Davison et al., 2007
    Observed in:
    DISEASE ASSOCIATED WITH ikbkg HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Bloch-Sulzberger syndrome Alliance Incontinentia pigmenti 308300
    hypohidrotic ectodermal dysplasia Alliance Ectodermal dysplasia and immunodeficiency 1 300291
    Immunodeficiency 33 300636
    DISEASE ASSOCIATED WITH ikbkg VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process I-kappaB phosphorylation (more)
    Cellular Component cytoplasm (more)
    Molecular Function protein binding (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ikbkg-201 (1)    Ensembl 2448
    ikbkg-202 (1)    Ensembl 2054
    ncRNA ikbkg-003 (1)    Ensembl 830
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ikbkg No data available
    MARKER RELATIONSHIPS
    ikbkg Contained in: [BAC] CH211-272P8 (1), DKEY-95F11 (1) (order this)
    ikbkg Encodes: [EST] fj33c07, IMAGE:7147563 (1)
    [cDNA] MGC:113492 (1), MGC:193114 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001014344 (1) 2480 nt
    Genomic GenBank:CR354375 (1) 133570 nt
    Select Tool
    Polypeptide UniProtKB:F1QHG7 (1) 602 aa
    Sequence Information (all 26)
    ORTHOLOGY for ikbkg ( Chr: 23 )
    CITATIONS (30)