Gene

man2b1

ID
ZDB-GENE-050327-52
Name
mannosidase, alpha, class 2B, member 1
Symbol
man2b1 Nomenclature History
Previous Names
  • zgc:110815
Type
protein_coding_gene
Location
Chr: 11 Mapping Details/Browsers
Description
Predicted to have alpha-mannosidase activity. Predicted to be involved in mannose metabolic process. Predicted to localize to lysosome and vacuolar membrane. Human ortholog(s) of this gene implicated in alpha-mannosidosis. Orthologous to human MAN2B1 (mannosidase alpha class 2B member 1).
Genome Resources
Note
None
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With man2b1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
alpha-mannosidosis Alliance Mannosidosis, alpha-, types I and II 248500
Associated With man2b1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000602 Glycoside hydrolase family 38, N-terminal domain
Domain IPR011682 Glycosyl hydrolase family 38, C-terminal
Domain IPR015341 Glycoside hydrolase family 38, central domain
Domain IPR041147 Glycosyl hydrolases family 38, C-terminal beta sandwich domain
Homologous_superfamily IPR011013 Galactose mutarotase-like domain superfamily
Homologous_superfamily IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel
Homologous_superfamily IPR013780 Glycosyl hydrolase, all-beta
Homologous_superfamily IPR027291 Glycoside hydrolase 38, N-terminal domain superfamily
Homologous_superfamily IPR028995 Glycoside hydrolase families 57/38, central domain superfamily
Homologous_superfamily IPR037094 Glycoside hydrolase family 38, central domain superfamily
Domain Details Per Protein
Protein Length Galactose mutarotase-like domain superfamily Glycoside hydrolase 38, N-terminal domain superfamily Glycoside hydrolase/deacetylase, beta/alpha-barrel Glycoside hydrolase families 57/38, central domain superfamily Glycoside hydrolase family 38, central domain Glycoside hydrolase family 38, central domain superfamily Glycoside hydrolase family 38, N-terminal domain Glycosyl hydrolase, all-beta Glycosyl hydrolase family 38, C-terminal Glycosyl hydrolases family 38, C-terminal beta sandwich domain
UniProtKB:E9QDW2 259
UniProtKB:F1QTT0 982
UniProtKB:Q58EM3 982
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations