ZFIN ID: ZDB-GENE-050327-52
Gene Name: mannosidase, alpha, class 2B, member 1
Gene Symbol: man2b1    Nomenclature History

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Previous Name: zgc:110815

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 11 Mapping Details/Browsers
Description: Predicted to have alpha-mannosidase activity. Predicted to be involved in mannose metabolic process and protein deglycosylation. Predicted to localize to vacuolar membrane. Human ortholog(s) of this gene implicated in alpha-mannosidosis. Orthologous to human MAN2B1 (mannosidase alpha class 2B member 1).
Genome Resources: Alliance (1),  Gene:541519 (1),  Ensembl(GRCz11):ENSDARG00000001897 (2)
GENE EXPRESSION
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa4425 Point Mutation Unknown Splice Site ENU
sa7293 Point Mutation Unknown Premature Stop ENU
sa12135 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa31840 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41874 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-man2b1
    3
    CRISPR2-man2b1
    1
    CRISPR3-man2b1
    4
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH man2b1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    alpha-mannosidosis Alliance Mannosidosis, alpha-, types I and II 248500
    DISEASE ASSOCIATED WITH man2b1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process carbohydrate metabolic process (more)
    Cellular Component vacuolar membrane (more)
    Molecular Function alpha-mannosidase activity (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA man2b1-201 (1)    Ensembl 3346
    man2b1-202 (1)    Ensembl 898
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM man2b1 No data available
    MARKER RELATIONSHIPS
    man2b1 Contained in: [BAC] DKEY-238I5 (1) (order this)
    man2b1 Encodes: [cDNA] MGC:110815 (1), MGC:192767 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001014332 (1) 3325 nt
    Genomic GenBank:CR847925 (1) 157270 nt
    Select Tool
    Polypeptide UniProtKB:F1QTT0 (1) 982 aa
    Sequence Information (all 16)
    ORTHOLOGY for man2b1 ( Chr: 11 )
    CITATIONS (21)