Gene
ercc5
- ID
- ZDB-GENE-050327-28
- Name
- excision repair cross-complementation group 5
- Symbol
- ercc5 Nomenclature History
- Previous Names
-
- zgc:110827
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to have endodeoxyribonuclease activity and single-stranded DNA binding activity. Predicted to be involved in nucleotide-excision repair, DNA incision, 3'-to lesion. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in melanoma and xeroderma pigmentosum group G. Orthologous to human ERCC5 (ERCC excision repair 5, endonuclease).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:110827 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| cerebrooculofacioskeletal syndrome 3 | Alliance | Cerebrooculofacioskeletal syndrome 3 | 616570 |
| xeroderma pigmentosum group G | Alliance | Xeroderma pigmentosum, group G | 278780 |
| xeroderma pigmentosum group G | Alliance | Xeroderma pigmentosum, group G/Cockayne syndrome | 278780 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR008918 | Helix-hairpin-helix motif, class 2 |
| Conserved_site | IPR019974 | XPG conserved site |
| Domain | IPR006085 | XPG, N-terminal |
| Domain | IPR006086 | XPG-I domain |
| Family | IPR001044 | XPG/Rad2 endonuclease, eukaryotes |
| Family | IPR006084 | XPG/Rad2 endonuclease |
| Homologous_superfamily | IPR029060 | PIN-like domain superfamily |
| Homologous_superfamily | IPR036279 | 5'-3' exonuclease, C-terminal domain superfamily |
Domain Details Per Protein
| Protein | Length | 5'-3' exonuclease, C-terminal domain superfamily | Helix-hairpin-helix motif, class 2 | PIN-like domain superfamily | XPG conserved site | XPG-I domain | XPG, N-terminal | XPG/Rad2 endonuclease | XPG/Rad2 endonuclease, eukaryotes |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:F1QJS3
|
1010 |
Interactions and Pathways
No data available
Plasmids
No data available