ZFIN ID: ZDB-GENE-050327-28
Gene Name: excision repair cross-complementation group 5
Gene Symbol: ercc5    Nomenclature History

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Previous Name: zgc:110827

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Predicted to have endodeoxyribonuclease activity and single-stranded DNA binding activity. Predicted to be involved in nucleotide-excision repair, DNA incision, 3'-to lesion. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in melanoma and xeroderma pigmentosum group G. Orthologous to human ERCC5 (ERCC excision repair 5, endonuclease).
Genome Resources: Alliance (1),  Gene:541502 (1),  Ensembl(GRCz11):ENSDARG00000023678 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:110827]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
zko20a Indel Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • zko20b Indel Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-ercc5 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH ercc5 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    xeroderma pigmentosum group G Alliance Xeroderma pigmentosum, group G 278780
    Xeroderma pigmentosum, group G/Cockayne syndrome 278780
    Cerebrooculofacioskeletal syndrome 3 616570
    DISEASE ASSOCIATED WITH ercc5 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process DNA repair (more)
    Cellular Component nucleus (more)
    Molecular Function catalytic activity (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ercc5-203 (1)    Ensembl 3283
    ncRNA ercc5-002 (1)    Ensembl 839
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ercc5 No data available
    MARKER RELATIONSHIPS
    ercc5 Contained in: [BAC] CH73-41E3 (1), CH73-244F7 (1)
    ercc5 Encodes: [EST] fb73d04
    [cDNA] MGC:110827 (1), MGC:192528 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001014315 (1) 1670 nt
    Genomic GenBank:CU571081 (1) 130071 nt
    Select Tool
    Polypeptide UniProtKB:F1QJS3 (1) 1010 aa
    Sequence Information (all 25)
    ORTHOLOGY for ercc5 ( Chr: 1 )
    CITATIONS (24)