ZFIN ID: ZDB-GENE-050320-5
Gene Name: integrin, alpha 6b
Gene Symbol: itga6b    Nomenclature History

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Previous Names: fl20e08, si:dkey-18j14.1, wu:fl20e08, zgc:113088

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Involved in glial cell development and retina development in camera-type eye. Predicted to localize to integrin complex. Is expressed in myotome. Human ortholog(s) of this gene implicated in junctional epidermolysis bullosa and junctional epidermolysis bullosa with pyloric atresia. Orthologous to human ITGA6 (integrin subunit alpha 6).
Genome Resources: Alliance (1),  Gene:541320 (1),  Ensembl(GRCz11):ENSDARG00000069946 (1)
GENE EXPRESSION
All Expression Data: Fig. 4 from Sztal et al., 2012
Wild-type Stages, Structures: Larval:Protruding-mouth (72.0h-96.0h, 3.5mm) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
cu21 Small Deletion Unknown Unknown CRISPR
la011311Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la013622Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la021117Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la021118Tg Transgenic Insertion Unknown Unknown DNA
    sa1967 Point Mutation Unknown Premature Stop ENU
    sa10618 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa16239 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-itga6b 1
    CRISPR2-itga6b
    1
    DISEASE ASSOCIATED WITH itga6b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    junctional epidermolysis bullosa with pyloric atresia Alliance Epidermolysis bullosa, junctional, with pyloric stenosis 226730
    DISEASE ASSOCIATED WITH itga6b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process glial cell development (more)
    Cellular Component integral component of membrane (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    aberrant processed transcript itga6b-202 (1)    Ensembl 873
    mRNA itga6b-201 (1)    Ensembl 4254
    itga6b-203 (1)    Ensembl 921
    ncRNA itga6b-002 (1)    Ensembl 551
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM itga6b No data available
    MARKER RELATIONSHIPS
    itga6b Contained in: [BAC] DKEY-18J14 (1) (order this)
    itga6b Encodes: [EST] fl20e08
    [cDNA] MGC:113088 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001013448 (1) 4265 nt
    Genomic GenBank:BX548015 (1) 255582 nt Blast at MegaBLAST
    Polypeptide UniProtKB:B8A5K2 (1) 1085 aa
    Sequence Information (all 15)
    ORTHOLOGY for itga6b ( Chr: 1 )
    CITATIONS (27)