Gene

itga6b

ID
ZDB-GENE-050320-5
Name
integrin, alpha 6b
Symbol
itga6b Nomenclature History
Previous Names
  • fl20e08
  • si:dkey-18j14.1
  • wu:fl20e08
  • zgc:113088
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Predicted to be involved in cell adhesion and integrin-mediated signaling pathway. Predicted to localize to integrin complex. Human ortholog(s) of this gene implicated in junctional epidermolysis bullosa and junctional epidermolysis bullosa with pyloric atresia. Is expressed in myotome. Orthologous to human ITGA6 (integrin subunit alpha 6).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Sztal et al., 2012
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Charlton-Perkins et al., 2019
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With itga6b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Epidermolysis bullosa, junctional 6, with pyloric atresia 619817
Associated With itga6b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site
Domain IPR013649 Integrin alpha-2
Family IPR000413 Integrin alpha chain
Homologous_superfamily IPR028994 Integrin alpha, N-terminal
Homologous_superfamily IPR032695 Integrin domain superfamily
Repeat IPR013517 FG-GAP repeat
Repeat IPR013519 Integrin alpha beta-propellor
Domain Details Per Protein
Protein Length FG-GAP repeat Integrin alpha-2 Integrin alpha beta-propellor Integrin alpha chain Integrin alpha chain, C-terminal cytoplasmic region, conserved site Integrin alpha, N-terminal Integrin domain superfamily
UniProtKB:A0A0R4IHK8 1080
UniProtKB:B8A5K2 1085
UniProtKB:F8W4L2 244
UniProtKB:F8W3N5 167
UniProtKB:Q5BLF7 1085
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations