ZFIN ID: ZDB-GENE-050320-3
Gene Name: speckle type BTB/POZ protein like a
Gene Symbol: spopla    Nomenclature History

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Previous Names: spopl, wu:fi71d08, zgc:101524 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Predicted to have ubiquitin protein ligase binding activity. Predicted to be involved in negative regulation of protein ubiquitination; proteasome-mediated ubiquitin-dependent protein catabolic process; and regulation of proteolysis. Predicted to localize to the Cul3-RING ubiquitin ligase complex; cytoplasm; and nucleus. Orthologous to human SPOPL (speckle type BTB/POZ protein like).
Genome Resources: Alliance (1),  Gene:541318 (1), 
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:101524]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la026710Tg Transgenic Insertion Unknown Unknown DNA
sa44702 Point Mutation Unknown Unknown ENU
PHENOTYPE No data available
DISEASE ASSOCIATED WITH spopla HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH spopla VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process negative regulation of protein ubiquitination (more)
Cellular Component Cul3-RING ubiquitin ligase complex (more)
Molecular Function ubiquitin protein ligase binding (more)
GO Terms (all 8)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Domain IPR000210 BTB/POZ domain
Domain IPR002083 MATH/TRAF domain
Homologous_superfamily IPR008974 TRAF-like
Homologous_superfamily IPR011333 SKP1/BTB/POZ domain superfamily
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA spopla-201 (1)    Ensembl 2565
Browsers: NCBI
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM spopla No data available
MARKER RELATIONSHIPS
spopla Contained in: [BAC] CH211-226C11 (1)
spopla Encodes: [EST] fi71d08
[cDNA] MGC:101524 (1)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_001013447 (1) 2554 bp
Genomic GenBank:AL954329 (1) 194284 bp
Select Tool
Polypeptide UniProtKB:Q5BL35 (1) 392 aa
Sequence Information (all 11)
ORTHOLOGY for spopla ( Chr: 9 )
CITATIONS (25)