ZFIN ID: ZDB-GENE-050320-144
Gene Name: cytochrome P450, family 2, subfamily X, polypeptide 6
Gene Symbol: cyp2x6    Nomenclature History

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Previous Name: zgc:110749

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 25 Mapping Details/Browsers
Description: Predicted to have heme binding activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; and steroid hydroxylase activity. Predicted to be involved in several processes, including exogenous drug catabolic process; organic acid metabolic process; and xenobiotic metabolic process. Predicted to localize to the cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in acute myeloid leukemia; asthma; autoimmune hepatitis; precursor lymphoblastic lymphoma/leukemia; and rhinitis. Orthologous to human CYP2D6 (cytochrome P450 family 2 subfamily D member 6).
Genome Resources: Alliance (1),  Gene:541440 (1),  Ensembl(GRCz11):ENSDARG00000079653 (1)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:6907986]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa16848 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa30231 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa44265 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH cyp2x6 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH cyp2x6 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process oxidation-reduction process (more)
    Cellular Component integral component of membrane (more)
    Molecular Function heme binding (more)
    GO Terms (all 16)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Family IPR001128 Cytochrome P450
    Family IPR002401 Cytochrome P450, E-class, group I
    Conserved_site IPR017972 Cytochrome P450, conserved site
    Homologous_superfamily IPR036396 Cytochrome P450 superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cyp2x6-201 (1)    Ensembl 1834
    cyp2x6-202 (1)    Ensembl 1693
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cyp2x6 No data available
    MARKER RELATIONSHIPS
    cyp2x6 Contained in: [BAC] DKEY-217G8 (1) (order this)
    cyp2x6 Encodes: [EST] IMAGE:6907986 (1)
    [cDNA] MGC:110749 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001013565 (1) 1890 bp
    Genomic GenBank:CU468035 (1) 225398 bp Blast at MegaBLAST
    Polypeptide UniProtKB:F1QSL5 (1) 491 aa
    Sequence Information (all 17)
    ORTHOLOGY for cyp2x6 ( Chr: 25 )
    CITATIONS (20)