Gene

dnmt3aa

ID

ZDB-GENE-050314-5

Name

DNA (cytosine-5-)-methyltransferase 3 alpha a

Symbol

dnmt3aa Nomenclature History

Previous Names

dnmt3a2 (1)
dnmt8

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Predicted to have DNA-methyltransferase activity. Predicted to be involved in DNA methylation and regulation of gene expression. Human ortholog(s) of this gene implicated in T-cell acute lymphoblastic leukemia; acute lymphoblastic leukemia; acute myeloid leukemia; myelodysplastic syndrome; and stomach cancer. Is expressed in several structures, including digestive system; nervous system; pleuroperitoneal region; spinal cord neural tube; and swim bladder bud. Orthologous to human DNMT3A (DNA methyltransferase 3 alpha).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

8 figures from 6 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 7 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dnmt3aa Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
acute myeloid leukemia	Alliance	Acute myeloid leukemia, somatic	601626
Tatton-Brown-Rahman syndrome	Alliance	Tatton-Brown-Rahman syndrome	615879
		Heyn-Sproul-Jackson syndrome	618724

Associated With dnmt3aa Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR018117	DNA methylase, C-5 cytosine-specific, active site
Domain	IPR000313	PWWP domain
Domain	IPR025766	ADD domain
Domain	IPR040552	DNMT3, cysteine rich ADD domain, GATA1-like zinc finger
Domain	IPR044108	DNA (cytosine-5)-methyltransferase 3A, ADD domain
Family	IPR001525	C-5 cytosine methyltransferase
Homologous_superfamily	IPR029063	S-adenosyl-L-methionine-dependent methyltransferase superfamily

Domain Details Per Protein

Protein	Length	ADD domain	C-5 cytosine methyltransferase	DNA (cytosine-5)-methyltransferase 3A, ADD domain	DNA methylase, C-5 cytosine-specific, active site	DNMT3, cysteine rich ADD domain, GATA1-like zinc finger	PWWP domain	S-adenosyl-L-methionine-dependent methyltransferase superfamily
UniProtKB:Q588C2 InterPro	852
UniProtKB:A0A8M2B825 InterPro	1010

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	dnmt3aa-201 (1) Ensembl	Havana	2905 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	dnmt3aa-202 (1) Ensembl	Havana	557 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations