Gene

dnmt3ab

ID
ZDB-GENE-050314-3
Name
DNA (cytosine-5-)-methyltransferase 3 alpha b
Symbol
dnmt3ab Nomenclature History
Previous Names
  • dnmt3a1 (1)
  • dnmt6
Type
protein_coding_gene
Location
Chr: 17 Mapping Details/Browsers
Description
Predicted to have DNA-methyltransferase activity. Predicted to be involved in DNA methylation and regulation of gene expression. Human ortholog(s) of this gene implicated in T-cell acute lymphoblastic leukemia; acute lymphoblastic leukemia; acute myeloid leukemia; myelodysplastic syndrome; and stomach cancer. Is expressed in several structures, including auditory capsule; digestive system; eye; pleuroperitoneal region; and spinal cord neural tube. Orthologous to human DNMT3A (DNA methyltransferase 3 alpha).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With dnmt3ab Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
acute myeloid leukemia Alliance Acute myeloid leukemia, somatic 601626
Heyn-Sproul-Jackson syndrome 618724
Tatton-Brown-Rahman syndrome 615879
Associated With dnmt3ab Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR018117 DNA methylase, C-5 cytosine-specific, active site
Domain IPR000313 PWWP domain
Domain IPR025766 ADD domain
Domain IPR040552 DNMT3, cysteine rich ADD domain
Domain IPR044108 DNA (cytosine-5)-methyltransferase 3A, ADD domain
Family IPR001525 C-5 cytosine methyltransferase
Family IPR030487 DNA (cytosine-5)-methyltransferase 3A
Homologous_superfamily IPR029063 S-adenosyl-L-methionine-dependent methyltransferase
Domain Details Per Protein
Protein Length ADD domain C-5 cytosine methyltransferase DNA (cytosine-5)-methyltransferase 3A DNA (cytosine-5)-methyltransferase 3A, ADD domain DNA methylase, C-5 cytosine-specific, active site DNMT3, cysteine rich ADD domain PWWP domain S-adenosyl-L-methionine-dependent methyltransferase
UniProtKB:Q588C4 731
UniProtKB:F1R1K5 978
UniProtKB:B3DGZ8 728
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations