ZFIN ID: ZDB-GENE-050309-70
Gene Name: spen family transcriptional repressor
Gene Symbol: spen    Nomenclature History

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Attributions

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Previous Names: im:7148349 (1), si:ch211-125c5.1

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 23 Mapping Details/Browsers
Description: Predicted to have RNA binding activity. Predicted to localize to the nucleus. Orthologous to human SPEN (spen family transcriptional repressor).
Genome Resources: Alliance (1),  Gene:503940 (1),  Ensembl(GRCz11):ENSDARG00000074245 (1)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7148349]
  1 figure (1 image) from Thisse et al., 2004 [IMAGE:7163861]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la022575Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la028519Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa14508 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa17259 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24329 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24330 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24331 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24332 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa29926 Point Mutation Unknown Premature Stop ENU
    sa37703 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37704 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43981 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH spen HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH spen VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Molecular Function nucleic acid binding (more)
    GO Terms (all 2)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000504 RNA recognition motif domain
    Domain IPR010912 Spen paralogue/orthologue C-terminal, metazoa
    Domain IPR012921 Spen paralogue and orthologue SPOC, C-terminal
    Domain IPR034172 SHARP, RNA recognition motif 1
    Domain IPR034173 SHARP, RNA recognition motif 2
    Domain IPR034174 SHARP, RNA recognition motif 3
    Domain IPR034175 SHARP, RNA recognition motif 4
    Homologous_superfamily IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
    Homologous_superfamily IPR016194 SPOC-like, C-terminal domain superfamily
    Homologous_superfamily IPR035979 RNA-binding domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA spen-201 (1)    Ensembl 10999
    ncRNA spen-002 (1) 599
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM spen No data available
    MARKER RELATIONSHIPS
    spen Contained in: [BAC] CH211-125C5 (1), DKEY-31B16 (1) (order this)
    spen Encodes: [EST] IMAGE:7148349 (1), IMAGE:7163861 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_003201204 (1)
    Genomic GenBank:BX957326 (1) 259092 nt Blast at MegaBLAST
    Polypeptide UniProtKB:F1QMN6 (1) 3476 aa
    Sequence Information (all 22)
    ORTHOLOGY for spen ( Chr: 23 )
    CITATIONS (22)