ZFIN ID: ZDB-GENE-050302-29
Gene Name: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A, a
Gene Symbol: dyrk1aa    Nomenclature History

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Previous Names: dyrk1a, im:6962097, zgc:158359

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Predicted to have protein serine/threonine kinase activity and transcription coactivator activity. Involved in angiogenesis and brain development. Predicted to localize to nucleus. Is expressed in endothelial cell; heart; nervous system; and pharyngeal arch. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in Down syndrome; autism spectrum disorder; autosomal dominant non-syndromic intellectual disability 7; and intellectual disability. Orthologous to human DYRK1A (dual specificity tyrosine phosphorylation regulated kinase 1A).
Genome Resources: Alliance (1),  Gene:100005019 (1),  Ensembl(GRCz11):ENSDARG00000063570 (2)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa15575 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21625 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa27522 Point Mutation Unknown Splice Site ENU
    zf2014 Small Deletion Exon 5 Frameshift, Premature Stop TALEN
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    TALEN1-dyrk1aa 1
    DISEASE ASSOCIATED WITH dyrk1aa HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal dominant non-syndromic intellectual disability 7 Alliance Mental retardation, autosomal dominant 7 614104
    DISEASE ASSOCIATED WITH dyrk1aa VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    autism spectrum disorder dyrk1aazf2014/zf2014 standard conditions (2)
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process angiogenesis (more)
    Cellular Component nucleus (more)
    Molecular Function ATP binding (more)
    GO Terms (all 16)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA dyrk1aa-203 (1)    Ensembl 695
    dyrk1aa-204 (1)    Ensembl 1216
    ncRNA dyrk1aa-003 (1) 424
    dyrk1aa-004 (1) 574
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM dyrk1aa No data available
    MARKER RELATIONSHIPS
    dyrk1aa Contained in: [Fosmid] CH1073-446E18 (1)
    dyrk1aa Encodes: [EST] IMAGE:6962097
    [cDNA] MGC:158359 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001080689 (1) 2420 nt
    Genomic GenBank:CU633885 (1) 40556 nt
    Select Tool
    Polypeptide UniProtKB:A1L1U2 (1) 737 aa
    Sequence Information (all 24)
    ORTHOLOGY for dyrk1aa ( Chr: 10 )
    CITATIONS (25)