Gene

dyrk1aa

ID
ZDB-GENE-050302-29
Name
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A, a
Symbol
dyrk1aa Nomenclature History
Previous Names
  • dyrk1a
  • im:6962097
  • zgc:158359
Type
protein_coding_gene
Location
Chr: 10 Mapping Details/Browsers
Description
Predicted to have protein serine/threonine kinase activity and transcription coactivator activity. Involved in angiogenesis and brain development. Predicted to localize to nucleus. Is expressed in endothelial cell; heart; nervous system; and pharyngeal arch. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in Down syndrome; autism spectrum disorder; autosomal dominant non-syndromic intellectual disability 7; and intellectual disability. Orthologous to human DYRK1A (dual specificity tyrosine phosphorylation regulated kinase 1A).
Genome Resources
Note
None
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
No data available
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
15 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With dyrk1aa Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal dominant non-syndromic intellectual disability 7 Alliance Mental retardation, autosomal dominant 7 614104
Associated With dyrk1aa Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Family IPR028318 Dual specificity tyrosine-phosphorylation-regulated kinase 1A/B
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Domain Details Per Protein
Protein Length Dual specificity tyrosine-phosphorylation-regulated kinase 1A/B Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine/threonine-protein kinase, active site
UniProtKB:A1L1U2 737
UniProtKB:E9QFG0 222
UniProtKB:E9QHB0 226
UniProtKB:F1QSN1 737
UniProtKB:A0A2R8QF25 733
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations