Gene

dock7

ID
ZDB-GENE-050302-15
Name
dedicator of cytokinesis 7
Symbol
dock7 Nomenclature History
Previous Names
  • fb93h07
  • im:7145816
  • im:7157388
  • wu:fb93h07
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in axonogenesis and positive regulation of GTPase activity. Predicted to act upstream of or within small GTPase mediated signal transduction. Is expressed in central nervous system; optic vesicle; and retina. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 23. Orthologous to human DOCK7 (dedicator of cytokinesis 7).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
7 figures from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With dock7 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
developmental and epileptic encephalopathy 23 Alliance Developmental and epileptic encephalopathy 23 615859
Associated With dock7 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR021816 Dedicator of cytokinesis C/D, N-terminal
Domain IPR027007 C2 DOCK-type domain
Domain IPR027357 DOCKER domain
Domain IPR037808 Dedicator of cytokinesis C, C2 domain
Family IPR026791 Dedicator of cytokinesis
Homologous_superfamily IPR035892 C2 domain superfamily
Homologous_superfamily IPR043161 Dedicator of cytokinesis, C-terminal, lobe A
Homologous_superfamily IPR043162 Dedicator of cytokinesis, C-terminal, lobe C
Domain Details Per Protein
Protein Length C2 DOCK-type domain C2 domain superfamily Dedicator of cytokinesis Dedicator of cytokinesis C, C2 domain Dedicator of cytokinesis C/D, N-terminal Dedicator of cytokinesis, C-terminal, lobe A Dedicator of cytokinesis, C-terminal, lobe C DOCKER domain
UniProtKB:Q6DEK2 378
UniProtKB:Q4QRD5 295
UniProtKB:A0A0R4IYH6 936
UniProtKB:E9QF12 319
UniProtKB:Q5XJT1 337
UniProtKB:A4IG99 379
UniProtKB:Q1JQ50 375
UniProtKB:F1Q8Z1 2129
UniProtKB:A8KB00 566
UniProtKB:A0A2R8Q377 566
UniProtKB:Q0IIQ8 294
UniProtKB:A0A2R8RTB3 294
UniProtKB:A0A2R8RQJ0 349
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations