ZFIN ID: ZDB-GENE-050302-102
Gene Name: CREB binding protein b
Gene Symbol: crebbpb    Nomenclature History

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Previous Names: CBP-A (1), CREBBPa (1), Zfcbp (1), gb:dq017638, im:7150488, si:ch211-121i18.1, wu:fp53a03

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Predicted to have histone acetyltransferase activity; transcription coactivator activity; and zinc ion binding activity. Predicted to be involved in histone acetylation and regulation of transcription, DNA-templated. Predicted to localize to histone acetyltransferase complex. Is expressed in somite. Human ortholog(s) of this gene implicated in Rubinstein-Taybi syndrome; acute lymphoblastic leukemia; and acute myeloid leukemia. Orthologous to human CREBBP (CREB binding protein).
Genome Resources: Alliance (1),  Gene:567111 (1),  Ensembl(GRCz11):ENSDARG00000112452 (1)
GENE EXPRESSION
All Expression Data: 11 figures from 4 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7150488]
  7 figures (7 images) from Thisse et al., 2008 [dq017638]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la023862Tg Transgenic Insertion Unknown Unknown DNA
sa919 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa33098 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38373 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40001 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-crebbpb N/A 1
    MO2-crebbpb N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH crebbpb HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Rubinstein-Taybi syndrome Alliance Rubinstein-Taybi syndrome 1 180849
    Menke-Hennekam syndrome 1 618332
    DISEASE ASSOCIATED WITH crebbpb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process histone acetylation (more)
    Cellular Component histone acetyltransferase complex (more)
    Molecular Function histone acetyltransferase activity (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA crebbpb-201 (1)    Ensembl 9022
    Browsers: NCBI
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM crebbpb No data available
    MARKER RELATIONSHIPS
    crebbpb Contained in: [BAC] CH211-87F11 (1), CH211-121I18 (1), CH211-200K23 (1), DKEY-29P9 (order this)
    crebbpb Encodes: [EST] dq017638 (1), fp53a03, IMAGE:7150488 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001365186 (1)
    Genomic GenBank:CR846080 (1) 242078 nt Blast at MegaBLAST
    Polypeptide UniProtKB:A0A0R4IY90 (1) 2443 aa
    Sequence Information (all 30)
    ORTHOLOGY for crebbpb ( Chr: 3 )
    CITATIONS (35)