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Gene

crebbpb

ID
ZDB-GENE-050302-102
Name
CREB binding protein b
Symbol
crebbpb Nomenclature History
Previous Names
  • CBP-A (1)
  • CREBBPa (1)
  • Zfcbp (1)
  • gb:dq017638
  • im:7150488
  • si:ch211-121i18.1
  • wu:fp53a03
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Predicted to enable chromatin DNA binding activity; histone acetyltransferase activity; and transcription coactivator activity. Predicted to be involved in histone acetylation and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of transcription, DNA-templated and rhythmic process. Predicted to be located in cytoplasm and nucleus. Predicted to be part of histone acetyltransferase complex and transcription regulator complex. Is expressed in somite. Human ortholog(s) of this gene implicated in Rubinstein-Taybi syndrome; acute lymphoblastic leukemia; and acute myeloid leukemia. Orthologous to human CREBBP (CREB binding protein).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
12 figures from 5 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With crebbpb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Rubinstein-Taybi syndrome Alliance Rubinstein-Taybi syndrome 1 180849
Menke-Hennekam syndrome 1 618332
Associated With crebbpb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018359 Bromodomain, conserved site
Domain IPR000197 Zinc finger, TAZ-type
Domain IPR000433 Zinc finger, ZZ-type
Domain IPR001487 Bromodomain
Domain IPR003101 Coactivator CBP, KIX domain
Domain IPR010303 CREB-binding protein/p300, atypical RING domain
Domain IPR014744 Nuclear receptor coactivator, CREB-bp-like, interlocking
Domain IPR031162 CBP/p300-type histone acetyltransferase domain
Family IPR013178 Histone acetyltransferase Rtt109/CBP
Homologous_superfamily IPR009110 Nuclear receptor coactivator, interlocking
Homologous_superfamily IPR013083 Zinc finger, RING/FYVE/PHD-type
Homologous_superfamily IPR035898 TAZ domain superfamily
Homologous_superfamily IPR036427 Bromodomain-like superfamily
Homologous_superfamily IPR036529 Coactivator CBP, KIX domain superfamily
Homologous_superfamily IPR038547 CBP/p300, atypical RING domain superfamily
Homologous_superfamily IPR043145 Zinc finger, ZZ-type superfamily
Domain Details Per Protein
Protein Length Bromodomain Bromodomain, conserved site Bromodomain-like superfamily CBP/p300, atypical RING domain superfamily CBP/p300-type histone acetyltransferase domain Coactivator CBP, KIX domain Coactivator CBP, KIX domain superfamily CREB-binding protein/p300, atypical RING domain Histone acetyltransferase Rtt109/CBP Nuclear receptor coactivator, CREB-bp-like, interlocking Nuclear receptor coactivator, interlocking TAZ domain superfamily Zinc finger, RING/FYVE/PHD-type Zinc finger, TAZ-type Zinc finger, ZZ-type Zinc finger, ZZ-type superfamily
UniProtKB:A0A0R4IY90 2443
UniProtKB:A0A0R4IVZ7 2431
UniProtKB:Q1L668 194
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations