Gene

dlg1l

ID
ZDB-GENE-050222-3
Name
discs, large (Drosophila) homolog 1, like
Symbol
dlg1l Nomenclature History
Previous Names
  • SAP-97B (1)
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Predicted to have phosphatase binding activity and protein kinase binding activity. Predicted to be involved in several processes, including actin cytoskeleton organization; endothelial cell proliferation; and protein localization to membrane. Predicted to colocalize with ionotropic glutamate receptor complex. Is expressed in retina; spinal cord; and tegmentum. Human ortholog(s) of this gene implicated in invasive ductal carcinoma. Orthologous to human DLG1 (discs large MAGUK scaffold protein 1).
Genome Resources
Note
None
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With dlg1l Human Ortholog
No data available
Associated With dlg1l Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR020590 Guanylate kinase, conserved site
Domain IPR001452 SH3 domain
Domain IPR001478 PDZ domain
Domain IPR004172 L27 domain
Domain IPR008144 Guanylate kinase-like domain
Domain IPR008145 Guanylate kinase/L-type calcium channel beta subunit
Domain IPR015143 L27-1
Domain IPR019583 PDZ-associated domain of NMDA receptors
Domain IPR019590 Disks large homologue 1, N-terminal PEST domain
Family IPR016313 Disks large 1-like
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR036028 SH3-like domain superfamily
Homologous_superfamily IPR036034 PDZ superfamily
Homologous_superfamily IPR036892 L27 domain superfamily
Domain Details Per Protein
Protein Length Disks large 1-like Disks large homologue 1, N-terminal PEST domain Guanylate kinase, conserved site Guanylate kinase-like domain Guanylate kinase/L-type calcium channel beta subunit L27-1 L27 domain L27 domain superfamily PDZ-associated domain of NMDA receptors PDZ domain PDZ superfamily P-loop containing nucleoside triphosphate hydrolase SH3 domain SH3-like domain superfamily
UniProtKB:A0A2R8Q3K7 60
UniProtKB:A0A0R4IEK3 906
UniProtKB:A0A0R4IJV7 224
UniProtKB:Q5PYH5 827
UniProtKB:A0A0R4IVS8 630
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations