ZFIN ID: ZDB-GENE-050220-14
Gene Name: retinoblastoma binding protein 8
Gene Symbol: rbbp8    Nomenclature History

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Previous Name: zgc:113143

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 24 Mapping Details/Browsers
Description: Predicted to have DNA binding activity and single-stranded DNA endodeoxyribonuclease activity. Predicted to be involved in DNA double-strand break processing involved in repair via single-strand annealing and double-strand break repair via homologous recombination. Predicted to localize to site of double-strand break. Human ortholog(s) of this gene implicated in Seckel syndrome 2. Orthologous to human RBBP8 (RB binding protein 8, endonuclease).
Genome Resources: Alliance (1),  Gene:503536 (1),  Ensembl(GRCz11):ENSDARG00000043480 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:113143]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-rbbp8
1
CRISPR2-rbbp8
1
PHENOTYPE No data available
DISEASE ASSOCIATED WITH rbbp8 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Seckel syndrome 2 Alliance Seckel syndrome 2 606744
Jawad syndrome 251255
Pancreatic carcinoma, somatic
DISEASE ASSOCIATED WITH rbbp8 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process cell cycle (more)
Cellular Component nucleus (more)
Molecular Function DNA binding (more)
GO Terms (all 20)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA rbbp8-201 (1)    Ensembl 2532
rbbp8-202 (1)    Ensembl 406
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM rbbp8 No data available
MARKER RELATIONSHIPS
rbbp8 Contained in: [BAC] CH73-374C3 (1), CH211-40K21 (1)
rbbp8 Encodes: [cDNA] MGC:113143 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001012500 (1) 2485 nt
Genomic GenBank:FP089511 (1) 158292 nt
Select Tool
Polypeptide UniProtKB:F1R983 (1) 651 aa
Sequence Information (all 14)
ORTHOLOGY for rbbp8 ( Chr: 24 )
CITATIONS (21)