ZFIN ID: ZDB-GENE-050220-10
Gene Name: peptidase, mitochondrial processing subunit beta
Gene Symbol: pmpcb    Nomenclature History

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Previous Name: zgc:110738 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 4 Mapping Details/Browsers
Description: Predicted to contribute to endopeptidase activity. Predicted to be involved in protein processing involved in protein targeting to mitochondrion. Predicted to localize to mitochondrial inner membrane and mitochondrial processing peptidase complex. Human ortholog(s) of this gene implicated in multiple mitochondrial dysfunctions syndrome 6. Orthologous to human PMPCB (peptidase, mitochondrial processing subunit beta).
Genome Resources: Alliance (1),  Gene:503532 (1),  Ensembl(GRCz11):ENSDARG00000016979 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:110738]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la028984Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH pmpcb HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    multiple mitochondrial dysfunctions syndrome 6 Alliance Multiple mitochondrial dysfunctions syndrome 6 617954
    DISEASE ASSOCIATED WITH pmpcb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process protein processing involved in protein targeting to mitochondrion (more)
    Cellular Component mitochondrial processing peptidase complex (more)
    Molecular Function catalytic activity (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA pmpcb-201 (1)    Ensembl 1625
    ncRNA pmpcb-002 (1)    Ensembl 789
    pmpcb-003 (1)    Ensembl 732
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM pmpcb No data available
    MARKER RELATIONSHIPS
    pmpcb Contained in: [BAC] CH211-203H15 (1)
    pmpcb Encodes: [cDNA] MGC:110738 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001012496 (1) 1560 nt
    Genomic GenBank:CR847994 (1) 100991 nt
    Select Tool
    Polypeptide UniProtKB:Q1L8E2 (1) 470 aa
    Sequence Information (all 9)
    ORTHOLOGY for pmpcb ( Chr: 4 )
    CITATIONS (21)