Gene

dlg3

ID
ZDB-GENE-050208-93
Name
discs, large homolog 3 (Drosophila)
Symbol
dlg3 Nomenclature History
Previous Names
  • fa66c08
  • fa66e02
  • fd02c12
  • fu95c12
  • im:7138640 (1)
  • si:ch211-276g21.1 (1)
  • wu:fa66c08 (1)
  • wu:fa66e02 (1)
  • wu:fd02c12 (1)
  • wu:fu95c12 (1)
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Predicted to be involved in several processes, including establishment or maintenance of epithelial cell apical/basal polarity; receptor clustering; and receptor localization to synapse. Predicted to colocalize with ionotropic glutamate receptor complex. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability. Is expressed in central nervous system; immature eye; notochord; sensory system; and ventral mesoderm. Orthologous to human DLG3 (discs large MAGUK scaffold protein 3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
7 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With dlg3 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
non-syndromic X-linked intellectual disability 90 Alliance Intellectual developmental disorder, X-linked 90 300850
Associated With dlg3 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR020590 Guanylate kinase, conserved site
Domain IPR001452 SH3 domain
Domain IPR001478 PDZ domain
Domain IPR008144 Guanylate kinase-like domain
Domain IPR008145 Guanylate kinase/L-type calcium channel beta subunit
Domain IPR019583 PDZ-associated domain of NMDA receptors
Domain IPR019590 Disks large homologue 1, N-terminal PEST domain
Domain IPR035763 Disks Large homologue 3, SH3 domain
Family IPR016313 Disks large 1-like
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR036028 SH3-like domain superfamily
Homologous_superfamily IPR036034 PDZ superfamily
Domain Details Per Protein
Protein Length Disks large 1-like Disks large homologue 1, N-terminal PEST domain Disks Large homologue 3, SH3 domain Guanylate kinase, conserved site Guanylate kinase-like domain Guanylate kinase/L-type calcium channel beta subunit PDZ-associated domain of NMDA receptors PDZ domain PDZ superfamily P-loop containing nucleoside triphosphate hydrolase SH3 domain SH3-like domain superfamily
UniProtKB:A0A0R4IIR7 153
UniProtKB:A0A0R4IVZ6 162
UniProtKB:A0A0R4INR9 272
UniProtKB:A0A2R8S051 860
UniProtKB:B0R131 348
UniProtKB:F1QS98 873
UniProtKB:A5PKT0 366
UniProtKB:A0A2R8QP28 855
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations