Gene

dlg3

ID

ZDB-GENE-050208-93

Name

discs, large homolog 3 (Drosophila)

Symbol

dlg3 Nomenclature History

Previous Names

fa66c08
fa66e02
fd02c12
fu95c12
im:7138640 (1)
si:ch211-276g21.1 (1)
wu:fa66c08 (1)
wu:fa66e02 (1)
wu:fd02c12 (1)
wu:fu95c12 (1)

Type

protein_coding_gene

Location

Chr: 14 Mapping Details/Browsers

Description

Predicted to be involved in several processes, including establishment or maintenance of epithelial cell apical/basal polarity; receptor clustering; and receptor localization to synapse. Predicted to colocalize with ionotropic glutamate receptor complex. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability. Is expressed in central nervous system; immature eye; notochord; sensory system; and ventral mesoderm. Orthologous to human DLG3 (discs large MAGUK scaffold protein 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

7 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

IMAGE:7138640 (10 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dlg3 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
non-syndromic X-linked intellectual disability 90	Alliance	Intellectual developmental disorder, X-linked 90	300850

Associated With dlg3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR020590	Guanylate kinase, conserved site
Domain	IPR001452	SH3 domain
Domain	IPR001478	PDZ domain
Domain	IPR008144	Guanylate kinase-like domain
Domain	IPR008145	Guanylate kinase/L-type calcium channel beta subunit
Domain	IPR019583	PDZ-associated domain of NMDA receptors
Domain	IPR019590	Disks large homologue 1, N-terminal PEST domain
Domain	IPR035763	Disks Large homologue 3, SH3 domain
Family	IPR016313	Disks large 1-like
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR036028	SH3-like domain superfamily
Homologous_superfamily	IPR036034	PDZ superfamily

Domain Details Per Protein

Protein	Length	Disks large 1-like	Disks large homologue 1, N-terminal PEST domain	Disks Large homologue 3, SH3 domain	Guanylate kinase, conserved site	Guanylate kinase-like domain	Guanylate kinase/L-type calcium channel beta subunit	PDZ-associated domain of NMDA receptors	PDZ domain	PDZ superfamily	P-loop containing nucleoside triphosphate hydrolase	SH3 domain	SH3-like domain superfamily
UniProtKB:A0A0R4IIR7 InterPro	153
UniProtKB:A0A0R4IVZ6 InterPro	162
UniProtKB:A0A0R4INR9 InterPro	272
UniProtKB:A0A2R8S051 InterPro	860
UniProtKB:B0R131 InterPro	348
UniProtKB:F1QS98 InterPro	873
UniProtKB:A5PKT0 InterPro	366
UniProtKB:A0A2R8QP28 InterPro	855

Transcripts

Genome Browsers

Type	Name	Length (nt)	Analysis
mRNA	dlg3-201 (1) Ensembl	2867 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	dlg3-202 (1) Ensembl	3960 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	dlg3-203 (1) Ensembl	485 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	dlg3-204 (1) Ensembl	460 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	dlg3-205 (1) Ensembl	963 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations