| ZFIN ID: ZDB-GENE-050208-93 |
| Gene Name: | discs, large homolog 3 (Drosophila) | |||||||||||||
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| Gene Symbol: | dlg3 Nomenclature History |
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Attributions
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| Previous Names: | fa66c08, fa66e02, fd02c12, fu95c12, im:7138640 (1), si:ch211-276g21.1 (1), wu:fa66c08 (1), wu:fa66e02 (1), wu:fd02c12 (1), wu:fu95c12 (1) | |||||||||||||
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| Gene Type: | protein_coding_gene | |||||||||||||
| Location: | Chr: 14 Mapping Details/Browsers | |||||||||||||
| Description: | Predicted to have ionotropic glutamate receptor binding activity. Predicted to be involved in several processes, including establishment or maintenance of epithelial cell apical/basal polarity; receptor clustering; and receptor localization to synapse. Predicted to colocalize with the ionotropic glutamate receptor complex. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability. Is expressed in central nervous system; immature eye; notochord; sensory system; and ventral mesoderm. Orthologous to human DLG3 (discs large MAGUK scaffold protein 3). | |||||||||||||
| Genome Resources: | Alliance (1), Gene:564081 (1), Ensembl(GRCz11):ENSDARG00000076796 (1) | |||||||||||||
| All Expression Data: | 7 figures from 2 publications |
| Directly Submitted Expression Data: | 6 figures (10 images) from Thisse et al., 2004 [IMAGE:7138640] |
| Wild-type Stages, Structures: | Segmentation:1-4 somites (10.33h-11.66h) to Hatching:Long-pec (48.0h-60.0h) |
| Curated Microarray Expression: | GEO (1) |
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
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| non-syndromic X-linked intellectual disability | Alliance | Mental retardation, X-linked 90 | 300850 |
| Ontology | GO Term |
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| Biological Process | cell-cell adhesion (more) |
| Cellular Component | basolateral plasma membrane (more) |
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| Type | Name | Length (nt) | Analysis | |
|---|---|---|---|---|
| mRNA |
dlg3-201
(1)
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2867 |
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dlg3-202
(1)
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3960 |
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dlg3-203
(1)
|
485 |
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dlg3-204
(1)
|
460 |
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dlg3-205
(1)
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963 |
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| Browsers: UCSC, NCBI, Ensembl, ZFIN |
| dlg3 Contained in: | [BAC] CH211-276G21 (1) (order this), DKEY-1A23 (1) (order this), DKEY-183E23 (1) (order this) |
| dlg3 Encodes: |
[EST]
fa66c08 (1),
fa66e02,
fd02c12,
fu95c12,
IMAGE:7138640 (1) (order this)
[cDNA] MGC:162970 (1) (order this) |
| Type | Accession # | Length (bp/aa) | Analysis |
|---|---|---|---|
| RNA | RefSeq:NM_001098742 (1) | 1771 bp |
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| Genomic | GenBank:CR759732 (1) | 225630 bp | Blast at MegaBLAST |
| Polypeptide | UniProtKB:F1QS98 (1) | 873 aa |
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| Sequence Clusters | UniGene:75998 (1) |
