ZFIN ID: ZDB-GENE-050208-93
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Gene Name: discs, large homolog 3 (Drosophila)
Gene Symbol: dlg3    Nomenclature History

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Previous Names: fa66c08, fa66e02, fd02c12, fu95c12, im:7138640 (1), si:ch211-276g21.1 (1), wu:fa66c08 (1), wu:fa66e02 (1), wu:fd02c12 (1), wu:fu95c12 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 14 Mapping Details/Browsers
Description: Predicted to have ionotropic glutamate receptor binding activity. Predicted to be involved in several processes, including establishment or maintenance of epithelial cell apical/basal polarity; receptor clustering; and receptor localization to synapse. Predicted to colocalize with the ionotropic glutamate receptor complex. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability. Is expressed in central nervous system; immature eye; notochord; sensory system; and ventral mesoderm. Orthologous to human DLG3 (discs large MAGUK scaffold protein 3).
Genome Resources: Alliance (1),  Gene:564081 (1),  Ensembl(GRCz11):ENSDARG00000076796 (1)
GENE EXPRESSION
All Expression Data: 7 figures from 2 publications
Directly Submitted Expression Data: 6 figures (10 images) from Thisse et al., 2004 [IMAGE:7138640]
Wild-type Stages, Structures: Segmentation:1-4 somites (10.33h-11.66h) to Hatching:Long-pec (48.0h-60.0h)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS No data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH dlg3 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
non-syndromic X-linked intellectual disability Alliance Mental retardation, X-linked 90 300850
DISEASE ASSOCIATED WITH dlg3 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process cell-cell adhesion (more)
Cellular Component basolateral plasma membrane (more)
GO Terms (all 10)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Domain IPR001452 SH3 domain
Domain IPR001478 PDZ domain
Domain IPR008144 Guanylate kinase-like domain
Domain IPR008145 Guanylate kinase/L-type calcium channel beta subunit
Family IPR016313 Disks large 1-like
Domain IPR019583 PDZ-associated domain of NMDA receptors
Domain IPR019590 Disks large homologue 1, N-terminal PEST domain
Conserved_site IPR020590 Guanylate kinase, conserved site
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Domain IPR035763 Disks Large homologue 3, SH3 domain
Homologous_superfamily IPR036028 SH3-like domain superfamily
Homologous_superfamily IPR036034 PDZ superfamily
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA dlg3-201 (1)    Ensembl 2867
Select Tool
dlg3-202 (1)    Ensembl 3960
Select Tool
dlg3-203 (1)    Ensembl 485
Select Tool
dlg3-204 (1)    Ensembl 460
Select Tool
dlg3-205 (1)    Ensembl 963
Select Tool
Browsers: UCSC,  NCBI,  Ensembl,  ZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM dlg3 No data available
MARKER RELATIONSHIPS
dlg3 Contained in: [BAC] CH211-276G21 (1), DKEY-1A23 (1) (order this), DKEY-183E23 (1) (order this)
dlg3 Encodes: [EST] fa66c08 (1), fa66e02, fd02c12, fu95c12, IMAGE:7138640 (1)
[cDNA] MGC:162970 (1)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_001098742 (1) 1771 bp
Select Tool
Genomic GenBank:CR759732 (1) 225630 bp Blast at MegaBLAST
Polypeptide UniProtKB:F1QS98 (1) 873 aa
Select Tool
Sequence Information (all 109)
ORTHOLOGY for dlg3 ( Chr: 14 )
CITATIONS (20)