Gene

dlg3

ID
ZDB-GENE-050208-93
Name
discs, large homolog 3 (Drosophila)
Symbol
dlg3 Nomenclature History
Previous Names
  • fa66c08
  • fa66e02
  • fd02c12
  • fu95c12
  • im:7138640 (1)
  • si:ch211-276g21.1 (1)
  • wu:fa66c08 (1)
  • wu:fa66e02 (1)
  • wu:fd02c12 (1)
  • wu:fu95c12 (1)
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Predicted to be involved in several processes, including establishment or maintenance of epithelial cell apical/basal polarity; receptor clustering; and receptor localization to synapse. Predicted to colocalize with ionotropic glutamate receptor complex. Is expressed in central nervous system; immature eye; notochord; sensory system; and ventral mesoderm. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability. Orthologous to human DLG3 (discs large MAGUK scaffold protein 3).
Genome Resources
Note
None
Expression
All Expression Data
7 figures from 2 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With dlg3 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
non-syndromic X-linked intellectual disability 90 Alliance Mental retardation, X-linked 90 300850
Associated With dlg3 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR020590 Guanylate kinase, conserved site
Domain IPR001452 SH3 domain
Domain IPR001478 PDZ domain
Domain IPR008144 Guanylate kinase-like domain
Domain IPR008145 Guanylate kinase/L-type calcium channel beta subunit
Domain IPR019583 PDZ-associated domain of NMDA receptors
Domain IPR019590 Disks large homologue 1, N-terminal PEST domain
Domain IPR035763 Disks Large homologue 3, SH3 domain
Family IPR016313 Disks large 1-like
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR036028 SH3-like domain superfamily
Homologous_superfamily IPR036034 PDZ superfamily
Domain Details Per Protein
Protein Length Disks large 1-like Disks large homologue 1, N-terminal PEST domain Disks Large homologue 3, SH3 domain Guanylate kinase, conserved site Guanylate kinase-like domain Guanylate kinase/L-type calcium channel beta subunit PDZ-associated domain of NMDA receptors PDZ domain PDZ superfamily P-loop containing nucleoside triphosphate hydrolase SH3 domain SH3-like domain superfamily
UniProtKB:A0A2R8QP28 855
UniProtKB:F1QS98 873
UniProtKB:A0A2R8S051 860
UniProtKB:A0A0R4IIR7 153
UniProtKB:A5PKT0 366
UniProtKB:A0A0R4INR9 272
UniProtKB:A0A0R4IVZ6 162
UniProtKB:B0R131 348
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations