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ZIRC
ZFIN ID: ZDB-GENE-050208-93
Gene Name: discs, large homolog 3 (Drosophila)
Gene Symbol: dlg3    Nomenclature History

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Previous Names: fa66c08, fa66e02, fd02c12, fu95c12, im:7138640 (1), si:ch211-276g21.1 (1), wu:fa66c08 (1), wu:fa66e02 (1), wu:fd02c12 (1), wu:fu95c12 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 14 Mapping Details/Browsers
Description: Predicted to have ionotropic glutamate receptor binding activity. Predicted to be involved in several processes, including establishment or maintenance of epithelial cell apical/basal polarity; receptor clustering; and receptor localization to synapse. Predicted to colocalize with the ionotropic glutamate receptor complex. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability. Is expressed in central nervous system; immature eye; notochord; sensory system; and ventral mesoderm. Orthologous to human DLG3 (discs large MAGUK scaffold protein 3).
Genome Resources: Alliance (1),  Gene:564081 (1),  Ensembl(GRCz11):ENSDARG00000076796 (1)
GENE EXPRESSION
All Expression Data: 7 figures from 2 publications
Directly Submitted Expression Data: 6 figures (10 images) from Thisse et al., 2004 [IMAGE:7138640]
Wild-type Stages, Structures: Segmentation:1-4 somites (10.33h-11.66h) to Hatching:Long-pec (48.0h-60.0h)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS No data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH dlg3 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
non-syndromic X-linked intellectual disability Alliance Mental retardation, X-linked 90 300850
DISEASE ASSOCIATED WITH dlg3 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process cell-cell adhesion (more)
Cellular Component basolateral plasma membrane (more)
GO Terms (all 10)
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA dlg3-201 (1)    Ensembl 2867
dlg3-202 (1)    Ensembl 3960
dlg3-203 (1)    Ensembl 485
dlg3-204 (1)    Ensembl 460
dlg3-205 (1)    Ensembl 963
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM dlg3 No data available
MARKER RELATIONSHIPS
dlg3 Contained in: [BAC] CH211-276G21 (1) (order this), DKEY-1A23 (1) (order this), DKEY-183E23 (1) (order this)
dlg3 Encodes: [EST] fa66c08 (1), fa66e02, fd02c12, fu95c12, IMAGE:7138640 (1) (order this)
[cDNA] MGC:162970 (1) (order this)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_001098742 (1) 1771 bp
Genomic GenBank:CR759732 (1) 225630 bp Blast at MegaBLAST
Polypeptide UniProtKB:F1QS98 (1) 873 aa
Sequence Clusters UniGene:75998 (1)
Sequence Information (all 110)
ORTHOLOGY for dlg3 ( Chr: 14 )
CITATIONS (19)