ZFIN ID: ZDB-GENE-050208-93
Gene Name: discs, large homolog 3 (Drosophila)
Gene Symbol: dlg3    Nomenclature History

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Previous Names: fa66c08, fa66e02, fd02c12, fu95c12, im:7138640 (1), si:ch211-276g21.1 (1), wu:fa66c08 (1), wu:fa66e02 (1), wu:fd02c12 (1), wu:fu95c12 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 14 Mapping Details/Browsers
Description: Predicted to be involved in several processes, including establishment or maintenance of epithelial cell apical/basal polarity; receptor clustering; and receptor localization to synapse. Predicted to colocalize with ionotropic glutamate receptor complex. Is expressed in central nervous system; immature eye; notochord; sensory system; and ventral mesoderm. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability. Orthologous to human DLG3 (discs large MAGUK scaffold protein 3).
Genome Resources: Alliance (1),  Gene:564081 (1),  Ensembl(GRCz11):ENSDARG00000076796 (1)
GENE EXPRESSION
All Expression Data: 7 figures from 2 publications
Directly Submitted Expression Data: 6 figures (10 images) from Thisse et al., 2004 [IMAGE:7138640]
Wild-type Stages, Structures: Segmentation:1-4 somites (10.33h-11.66h) to Hatching:Long-pec (48.0h-60.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS No data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH dlg3 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
non-syndromic X-linked intellectual disability Alliance Mental retardation, X-linked 90 300850
DISEASE ASSOCIATED WITH dlg3 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process cell-cell adhesion (more)
Cellular Component basolateral plasma membrane (more)
GO Terms (all 10)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA dlg3-201 (1)    Ensembl 2867
dlg3-202 (1)    Ensembl 3960
dlg3-203 (1)    Ensembl 485
dlg3-204 (1)    Ensembl 460
dlg3-205 (1)    Ensembl 963
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM dlg3 No data available
MARKER RELATIONSHIPS
dlg3 Contained in: [BAC] CH211-276G21 (1), DKEY-1A23 (1) (order this), DKEY-183E23 (1) (order this)
dlg3 Encodes: [EST] fa66c08 (1), fa66e02, fd02c12, fu95c12, IMAGE:7138640 (1)
[cDNA] MGC:162970 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001098742 (1) 1771 nt
Genomic GenBank:CR759732 (1) 225630 nt Blast at MegaBLAST
Polypeptide UniProtKB:F1QS98 (1) 873 aa
Sequence Information (all 109)
ORTHOLOGY for dlg3 ( Chr: 14 )
CITATIONS (20)