ZFIN ID: ZDB-GENE-050208-657
Gene Name: oxysterol binding protein-like 1A
Gene Symbol: osbpl1a    Nomenclature History

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Previous Name: si:dkey-121a11.8

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 22 Mapping Details/Browsers
Description: Predicted to have cholesterol binding activity and sterol transporter activity. Predicted to be involved in lipid transport. Predicted to localize to cytosol; intracellular membrane-bounded organelle; and membrane. Used to study visceral heterotaxy. Orthologous to human OSBPL1A (oxysterol binding protein like 1A).
Genome Resources: Alliance (1),  Gene:565503 (1),  Ensembl(GRCz11):ENSDARG00000105147 (1)
GENE EXPRESSION
All Expression Data: Fig. S7 from Burkhalter et al., 2019
Wild-type Stages, Structures: Segmentation:1-4 somites (10.33h-11.66h) to Segmentation:5-9 somites (11.66h-14.0h)
 
High Throughput Expression: Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la014167Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la014168Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa25178 Point Mutation Unknown Splice Site ENU
    sa37474 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39365 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-osbpl1a N/A 1
    PHENOTYPE
    Data: Fig. S12 from Burkhalter et al., 2019
    Observed in:
    DISEASE ASSOCIATED WITH osbpl1a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH osbpl1a VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    visceral heterotaxy WT + MO1-osbpl1a standard conditions Burkhalter et al., 2019
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process lipid transport (more)
    Cellular Component cytosol (more)
    Molecular Function cholesterol binding (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA osbpl1a-201 (1)    Ensembl 3299
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM osbpl1a No data available
    MARKER RELATIONSHIPS
    osbpl1a Contained in: [BAC] DKEY-6P9 (1) (order this), DKEY-121A11 (1) (order this), DKEY-168J9 (1) (order this)
    osbpl1a Encodes: [cDNA] MGC:194415 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_009296328 (1)
    Genomic GenBank:BX465190 (1) 183103 nt
    Select Tool
    Polypeptide UniProtKB:A0A0R4IQ17 (1) 972 aa
    Sequence Information (all 24)
    ORTHOLOGY for osbpl1a ( Chr: 22 )
    CITATIONS (22)