Gene

sirt7

ID

ZDB-GENE-050208-612

Name

sirtuin 7

Symbol

sirt7 Nomenclature History

Previous Names

si:ch211-258l4.6 (1)

Type

protein_coding_gene

Location

Chr: 22 Mapping Details/Browsers

Description

Predicted to have NAD-dependent histone deacetylase activity (H3-K18 specific) and transcription corepressor activity. Involved in hematopoietic progenitor cell differentiation. Predicted to localize to nuclear telomeric heterochromatin. Is expressed in retina. Orthologous to human SIRT7 (sirtuin 7).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

eu987 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Huang et al., 2013
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With sirt7 Human Ortholog

No data available

Associated With sirt7 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR026590	Sirtuin family, catalytic core domain
Family	IPR003000	Sirtuin family
Homologous_superfamily	IPR029035	DHS-like NAD/FAD-binding domain superfamily

Domain Details Per Protein

Protein	Length	DHS-like NAD/FAD-binding domain superfamily	Sirtuin family	Sirtuin family, catalytic core domain
UniProtKB:A0A2R8QUG9 InterPro	405

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	sirt7-201 (1) Ensembl	Havana	2575 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations