ZFIN ID: ZDB-GENE-050208-585
Gene Name: protein tyrosine phosphatase receptor type C
Gene Symbol: ptprc    Nomenclature History

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Previous Names: cd45 (1), sb:eu845, si:dkeyp-47c5.1

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 22 Mapping Details/Browsers
Description: Predicted to have protein tyrosine phosphatase activity. Predicted to be involved in negative regulation of protein kinase activity; positive regulation of peptidyl-tyrosine phosphorylation; and protein dephosphorylation. Predicted to localize to integral component of membrane. Is expressed in blood island; common myeloid progenitor; hematopoietic stem cell; intermediate cell mass of mesoderm; and ventral wall of dorsal aorta. Human ortholog(s) of this gene implicated in hepatitis C; multiple sclerosis; severe combined immunodeficiency; and severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, Nk cell-positive. Orthologous to human PTPRC (protein tyrosine phosphatase receptor type C).
Genome Resources: Alliance (1),  Gene:559154 (1),  Ensembl(GRCz11):ENSDARG00000071437 (2)
GENE EXPRESSION
All Expression Data: 9 figures from 6 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2005 [eu845]
Wild-type Stages, Structures: Pharyngula:Prim-5 (24.0h-30.0h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
PHENOTYPE No data available
DISEASE ASSOCIATED WITH ptprc HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, Nk cell-positive Alliance Severe combined immunodeficiency, T cell-negative, B-cell/natural killer-cell positive 608971
{Hepatitis C virus, susceptibility to} 609532
DISEASE ASSOCIATED WITH ptprc VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process dephosphorylation (more)
Cellular Component integral component of membrane (more)
Molecular Function hydrolase activity (more)
GO Terms (all 10)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA ptprc-202 (1)    Ensembl 3226
ptprc-203 (1)    Ensembl 771
Browsers: NCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM ptprc
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg(ptprc:DsRed) ptprc DsRed Danio rerio 1 10
MARKER RELATIONSHIPS
ptprc Contained in: [BAC] DKEYP-47C5 (1)
ptprc Encodes: [EST] eu845 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:XM_021469594 (1)
Genomic GenBank:BX469928 (1) 141594 nt
Select Tool
Polypeptide UniProtKB:F1R8P8 (1) 1130 aa
Sequence Information (all 22)
ORTHOLOGY for ptprc ( Chr: 22 )
CITATIONS (40)