Gene
pdgfba
- ID
- ZDB-GENE-050208-525
- Name
- platelet-derived growth factor beta polypeptide a
- Symbol
- pdgfba Nomenclature History
- Previous Names
-
- pdgfb
- sb:eu1033
- si:ch211-79m20.1
- si:dkey-261d11.1
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable platelet-derived growth factor receptor binding activity. Acts upstream of or within angiogenesis; regulation of DNA replication; and tissue regeneration. Predicted to be located in membrane. Predicted to be active in extracellular space. Is expressed in cardiovascular system; diencephalon; floor plate; head; and liver. Human ortholog(s) of this gene implicated in several diseases, including basal ganglia calcification; clear cell renal cell carcinoma; dermatofibrosarcoma protuberans; familial meningioma; and high grade glioma (multiple). Orthologous to human PDGFB (platelet derived growth factor subunit B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 17 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu1033 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| basal ganglia calcification | Alliance | Basal ganglia calcification, idiopathic, 5 | 615483 |
| dermatofibrosarcoma protuberans | Alliance | Dermatofibrosarcoma protuberans | 607907 |
| Meningioma, SIS-related | 607174 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR023581 | Platelet-derived growth factor, conserved site |
| Domain | IPR000072 | PDGF/VEGF domain |
| Domain | IPR006782 | Platelet-derived growth factor, N-terminal |
| Family | IPR015583 | Platelet-derived growth factor subunit B |
| Homologous_superfamily | IPR029034 | Cystine-knot cytokine |
Domain Details Per Protein
| Protein | Length | Cystine-knot cytokine | PDGF/VEGF domain | Platelet-derived growth factor, conserved site | Platelet-derived growth factor, N-terminal | Platelet-derived growth factor subunit B |
|---|---|---|---|---|---|---|
|
UniProtKB:Q1LUW1
|
265 | |||||
|
UniProtKB:F1QS30
|
434 | |||||
|
UniProtKB:A0A088AWM4
|
183 | |||||
|
UniProtKB:A0A2R8PYF1
|
463 |
| Type | Name | Length (nt) | Analysis |
|---|---|---|---|
| mRNA |
pdgfba-202
(1)
|
1195 nt |
Interactions and Pathways
No data available
Plasmids
No data available