Gene

nfia

ID

ZDB-GENE-050208-501

Name

nuclear factor I/A

Symbol

nfia Nomenclature History

Previous Names

si:ch211-88d2.2
wu:fq27e07
zgc:158351

Type

protein_coding_gene

Location

Chr: 22 Mapping Details/Browsers

Description

Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in NFIA-related disorder. Is expressed in brain. Orthologous to human NFIA (nuclear factor I A).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

14 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With nfia Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
NFIA-related disorder	Alliance	Brain malformations with or without urinary tract defects	613735

Associated With nfia Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019739	CTF transcription factor/nuclear factor 1, conserved site
Domain	IPR003619	MAD homology 1, Dwarfin-type
Domain	IPR019548	CTF transcription factor/nuclear factor 1, N-terminal
Domain	IPR020604	CTF transcription factor/nuclear factor 1, DNA-binding domain
Family	IPR000647	CTF transcription factor/nuclear factor 1

Domain Details Per Protein

Protein	Length	CTF transcription factor/nuclear factor 1	CTF transcription factor/nuclear factor 1, conserved site	CTF transcription factor/nuclear factor 1, DNA-binding domain	CTF transcription factor/nuclear factor 1, N-terminal	MAD homology 1, Dwarfin-type
UniProtKB:A0A8M3B5H7 InterPro	527
UniProtKB:A1A5X3 InterPro	481
UniProtKB:A0A8M3AM79 InterPro	570
UniProtKB:A0A8M3AUN3 InterPro	587
UniProtKB:A0A8M3AUN8 InterPro	564
UniProtKB:A0A8M3AM86 InterPro	544
UniProtKB:A0A8M3AMZ3 InterPro	567
UniProtKB:A0A8M3AXN2 InterPro	567

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	nfia-203 (1) Ensembl	Havana	3353 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	nfia-204 (1) Ensembl	Havana	782 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations