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ZIRC
ZFIN ID: ZDB-GENE-050208-492
Gene Name: BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
Gene Symbol: bap1    Nomenclature History

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Previous Name: si:dkey-42i9.9

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 22 Mapping Details/Browsers
Description: Predicted to have chromatin binding activity and thiol-dependent ubiquitin-specific protease activity. Involved in Notch signaling pathway and cranial skeletal system development. Predicted to localize to the PR-DUB complex and cytoplasm. Human ortholog(s) of this gene implicated in basal cell carcinoma. Orthologous to human BAP1 (BRCA1 associated protein 1).
Genome Resources: Alliance (1),  Gene:558885 (1),  Ensembl(GRCz11):ENSDARG00000063051 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2005 [eu310]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la014139Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24086 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24087 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24088 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa29731 Point Mutation Unknown Splice Site ENU
    sa31069 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39360 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-bap1 N/A 2
    MO2-bap1 N/A 1
    DISEASE ASSOCIATED WITH bap1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Tumor predisposition syndrome 614327
    DISEASE ASSOCIATED WITH bap1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cranial skeletal system development (more)
    Cellular Component cytoplasm (more)
    Molecular Function chromatin binding (more)
    GO Terms (all 20)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA bap1-201 (1)    Ensembl 3122
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM bap1 No data available
    MARKER RELATIONSHIPS
    bap1 Contained in: [BAC] DKEY-42I9 (1) (order this)
    bap1 Encodes: [EST] eu310 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001163837 (1) 3122 bp
    Genomic GenBank:BX465868 (1) 222195 bp Blast at MegaBLAST
    Polypeptide UniProtKB:A0A2R8Q190 (1) 756 aa
    Sequence Clusters UniGene:37720 (1)
    Sequence Information (all 21)
    ORTHOLOGY for bap1 ( Chr: 22 )
    CITATIONS (26)