ZFIN ID: ZDB-GENE-050208-453
Gene Name: tumor protein p53 binding protein, 2b
Gene Symbol: tp53bp2b    Nomenclature History

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Previous Names: aspp2b (1), si:dkeyp-34c12.2

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 22 Mapping Details/Browsers
Description: Predicted to have p53 binding activity. Involved in chordate embryonic development; cilium movement; and negative regulation of protein kinase B signaling. Localizes to cytoplasm. Is expressed in several structures, including gill; heart; liver; muscle; and pleuroperitoneal region. Orthologous to human TP53BP2 (tumor protein p53 binding protein 2).
Genome Resources: Alliance (1),  Gene:568138 (1),  Ensembl(GRCz11):ENSDARG00000054858 (1)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa3156 Point Mutation Unknown Premature Stop ENU
sa24196 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43870 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-tp53bp2b N/A 1
    DISEASE ASSOCIATED WITH tp53bp2b HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH tp53bp2b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process chordate embryonic development (more)
    Cellular Component cytoplasm (more)
    Molecular Function p53 binding (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA tp53bp2b-202 (1)    Ensembl 3187
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tp53bp2b No data available
    MARKER RELATIONSHIPS
    tp53bp2b Contained in: [BAC] DKEYP-34C12 (1)
    tp53bp2b Encodes: [cDNA] MGC:162759 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001045153 (1) 3187 nt
    Genomic GenBank:BX321898 (1) 195042 nt
    Select Tool
    Polypeptide UniProtKB:F1QWN1 (1) 1063 aa
    Sequence Information (all 18)
    ORTHOLOGY for tp53bp2b ( Chr: 22 )
    CITATIONS (17)