ZFIN ID: ZDB-GENE-050208-41
Gene Name: dachsous cadherin-related 1b
Gene Symbol: dchs1b    Nomenclature History

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Previous Names: dchs1, im:7136458 (1), im:7156059

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Predicted to have cadherin binding activity and calcium ion binding activity. Involved in several processes, including atrioventricular canal development; cortical granule exocytosis; and mitotic cleavage furrow formation. Predicted to localize to catenin complex. Is expressed in several structures, including blastomere; heart; mesoderm; musculature system; and retina. Human ortholog(s) of this gene implicated in Van Maldergem syndrome 1 and mitral valve prolapse. Orthologous to human DCHS1 (dachsous cadherin-related 1).
Genome Resources: Alliance (1),  Gene:553300 (1),  Ensembl(GRCz11):ENSDARG00000079850 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
dchs1b_unrecovered Point Mutation Unknown Unknown ENU
fh274 Point Mutation Unknown Premature Stop ENU
fh275 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la011174Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa10621 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21746 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21747 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa31782 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34914 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34915 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34916 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38802 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41669 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41670 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41671 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa44724 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-dchs1b
    2
    CRISPR2-dchs1b
    2
    CRISPR3-dchs1b
    2
    CRISPR4-dchs1b
    2
    CRISPR5-dchs1b
    2
    CRISPR6-dchs1b
    2
    CRISPR7-dchs1b
    2
    CRISPR8-dchs1b
    2
    MO1-dchs1b N/A 1
    DISEASE ASSOCIATED WITH dchs1b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    mitral valve prolapse Alliance Mitral valve prolapse 2 607829
    Van Maldergem syndrome 1 Alliance Van Maldergem syndrome 1 601390
    DISEASE ASSOCIATED WITH dchs1b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process atrioventricular canal development (more)
    Cellular Component integral component of membrane (more)
    Molecular Function protein binding (more)
    GO Terms (all 21)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA dchs1b-201 (1)    Ensembl 2170
    dchs1b-203 (1)    Ensembl 4224
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM dchs1b No data available
    MARKER RELATIONSHIPS
    dchs1b Contained in: [BAC] DKEY-22L17 (1) (order this)
    dchs1b Encodes: [EST] IMAGE:7136458 (1), IMAGE:7156059 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_021472280 (1)
    Genomic GenBank:BX530069 (1) 222308 nt Blast at MegaBLAST
    Polypeptide UniProtKB:F1QGX1 (1) 3298 aa
    Sequence Information (all 21)
    ORTHOLOGY for dchs1b ( Chr: 10 )
    CITATIONS (36)