ZFIN Gene: dchs1b

ZFIN ID: ZDB-GENE-050208-41

ZFIN ID: ZDB-GENE-050208-41

Gene Name:

dachsous cadherin-related 1b

Gene Symbol:

dchs1b Nomenclature History

Previous Names:

dchs1, im:7136458 (1), im:7156059

Gene Type:

protein_coding_gene

Location:

Chr: 10 Mapping Details/Browsers

Description:

Predicted to have cadherin binding activity and calcium ion binding activity. Involved in several processes, including atrioventricular canal development; cortical granule exocytosis; and mitotic cleavage furrow formation. Predicted to localize to catenin complex. Is expressed in several structures, including blastomere; heart; mesoderm; musculature system; and retina. Human ortholog(s) of this gene implicated in Van Maldergem syndrome 1 and mitral valve prolapse. Orthologous to human DCHS1 (dachsous cadherin-related 1).

Genome Resources:

Alliance (1), Gene:553300 (1), Ensembl(GRCz11):ENSDARG00000079850 (2)

GENE EXPRESSION
All Expression Data:	13 figures from 3 publications
Directly Submitted Expression Data:	5 figures (9 images) from Thisse et al., 2004 [IMAGE:7136458]
	6 figures (9 images) from Thisse et al., 2004 [IMAGE:7156059]
Wild-type Stages, Structures:	Zygote:1-cell (0.0h-0.75h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
	adaxial cell atrioventricular canal blastomere central nervous system heart hypaxial myotome region mesoderm pectoral fin musculature retina retinal ganglion cell layer somite whole organism
High Throughput Expression:	GEO (1) , Expression Atlas (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
dchs1b_unrecovered	Point Mutation	Unknown	Unknown	ENU
fh274	Point Mutation	Unknown	Premature Stop	ENU
fh275	Point Mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this)
la011174Tg	Transgenic Insertion	Unknown	Unknown	DNA	Zebrafish International Resource Center (ZIRC) (order this)
sa10621	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa21746	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa21747	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa31782	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa34914	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa34915	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa34916	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa38802	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa41669	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa41670	Point Mutation	Unknown	Unknown	ENU	Zebrafish International Resource Center (ZIRC) (order this)
sa41671	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa44724	Point Mutation	Unknown	Unknown	ENU	European Zebrafish Resource Center (EZRC) (order this)

Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Publications
CRISPR1-dchs1b		2
CRISPR2-dchs1b		2
CRISPR3-dchs1b		2
CRISPR4-dchs1b		2
CRISPR5-dchs1b		2
CRISPR6-dchs1b		2
CRISPR7-dchs1b		2
CRISPR8-dchs1b		2
MO1-dchs1b	N/A	1

PHENOTYPE

Data:

10 figures from 3 publications

Observed in:

DISEASE ASSOCIATED WITH dchs1b HUMAN ORTHOLOG

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
mitral valve prolapse	Alliance	Mitral valve prolapse 2	607829
Van Maldergem syndrome 1	Alliance	Van Maldergem syndrome 1	601390

DISEASE ASSOCIATED WITH dchs1b VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	atrioventricular canal development (more)
Cellular Component	integral component of membrane (more)
Molecular Function	protein binding (more)

GO Terms (all 21)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
mRNA	dchs1b-201 (1)	2170	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	dchs1b-203 (1)	4224	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Browsers: NCBI, Ensembl, ZFIN

INTERACTIONS AND PATHWAYS

ANTIBODIES No data available

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM dchs1b No data available

MARKER RELATIONSHIPS

dchs1b Contained in:	[BAC] DKEY-22L17 (1) (order this)
dchs1b Encodes:	[EST] IMAGE:7136458 (1), IMAGE:7156059 (1)

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:XM_021472280 (1)		Select Tool ZFIN BLAST NCBI BLAST MegaBLAST Ensembl UCSC BLAT
Genomic	GenBank:BX530069 (1)	222308 nt	Blast at MegaBLAST
Polypeptide	UniProtKB:F1QGX1 (1)	3298 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 21)

ORTHOLOGY for dchs1b ( Chr: 10 )

CITATIONS (36)

{{control.fieldName}} Edit

Attributions

Add new Alias

Attributions for Alias: {{control.newAlias}}

Delete Alias: