Gene
dchs1b
- ID
- ZDB-GENE-050208-41
- Name
- dachsous cadherin-related 1b
- Symbol
- dchs1b Nomenclature History
- Previous Names
-
- dchs1
- im:7136458 (1)
- im:7156059
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Is predicted to enable cadherin binding activity and calcium ion binding activity. Involved in several processes, including calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; cell morphogenesis; and cell-cell junction organization. Acts upstream of or within several processes, including atrioventricular canal development; cortical granule exocytosis; and mitotic cleavage furrow formation. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be part of catenin complex. Is expressed in several structures, including blastomere; heart; mesoderm; musculature system; and retina. Human ortholog(s) of this gene implicated in Van Maldergem syndrome 1 and mitral valve prolapse. Orthologous to human DCHS1 (dachsous cadherin-related 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7136458 (9 images)
- IMAGE:7156059 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
mitral valve prolapse | Alliance | Mitral valve prolapse 2 | 607829 |
Van Maldergem syndrome 1 | Alliance | Van Maldergem syndrome 1 | 601390 |
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Length | Cadherin conserved site | Cadherin-like | Cadherin-like superfamily |
---|---|---|---|---|
UniProtKB:F1QXA3
|
921 | |||
UniProtKB:Q5CZT3
|
436 | |||
UniProtKB:E9QEN9
|
274 | |||
UniProtKB:F1QGX1
|
3298 |
Type | Name | Length (nt) | Analysis |
---|---|---|---|
mRNA |
dchs1b-201
(1)
|
2170 nt | |
mRNA |
dchs1b-203
(1)
|
4224 nt |
Interactions and Pathways
No data available
Plasmids
No data available