Gene

dchs1b

ID

ZDB-GENE-050208-41

Name

dachsous cadherin-related 1b

Symbol

dchs1b Nomenclature History

Previous Names

dchs1
im:7136458 (1)
im:7156059

Type

protein_coding_gene

Location

Chr: 10 Mapping Details/Browsers

Description

Is predicted to enable cadherin binding activity and calcium ion binding activity. Involved in several processes, including calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; cell morphogenesis; and cell-cell junction organization. Acts upstream of or within several processes, including atrioventricular canal development; cortical granule exocytosis; and mitotic cleavage furrow formation. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be part of catenin complex. Is expressed in several structures, including blastomere; heart; mesoderm; musculature system; and retina. Human ortholog(s) of this gene implicated in Van Maldergem syndrome 1 and mitral valve prolapse. Orthologous to human DCHS1 (dachsous cadherin-related 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

13 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

IMAGE:7136458 (9 images)
IMAGE:7156059 (9 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 10 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dchs1b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
mitral valve prolapse	Alliance	Mitral valve prolapse 2	607829
Van Maldergem syndrome 1	Alliance	Van Maldergem syndrome 1	601390

Associated With dchs1b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR020894	Cadherin conserved site
Domain	IPR002126	Cadherin-like
Homologous_superfamily	IPR015919	Cadherin-like superfamily

Domain Details Per Protein

Protein	Length	Cadherin conserved site	Cadherin-like	Cadherin-like superfamily
UniProtKB:F1QXA3 InterPro	921
UniProtKB:Q5CZT3 InterPro	436
UniProtKB:E9QEN9 InterPro	274
UniProtKB:F1QGX1 InterPro	3298

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Length (nt)	Analysis
mRNA	dchs1b-201 (1) Ensembl	2170 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	dchs1b-203 (1) Ensembl	4224 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations