ZFIN ID: ZDB-GENE-050208-406
Gene Name: ceramide synthase 1
Gene Symbol: cers1    Nomenclature History

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Previous Names: si:dkey-49m19.7, wu:fb75h07

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 22 Mapping Details/Browsers
Description: Predicted to have sphingosine N-acyltransferase activity. Predicted to be involved in ceramide biosynthetic process. Predicted to localize to the endoplasmic reticulum. Human ortholog(s) of this gene implicated in progressive myoclonus epilepsy. Is expressed in several structures, including intermediate cell mass of mesoderm; intestine; nervous system; otic vesicle; and trigeminal neural crest. Orthologous to human CERS1 (ceramide synthase 1).
Genome Resources: Alliance (1),  Gene:568169 (1),  Ensembl(GRCz11):ENSDARG00000063412 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS No data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH cers1 HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH cers1 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process ceramide biosynthetic process (more)
Cellular Component integral component of membrane (more)
Molecular Function N-acyltransferase activity (more)
GO Terms (all 6)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Domain IPR006634 TRAM/LAG1/CLN8 homology domain
Family IPR016439 Sphingosine N-acyltransferase Lag1/Lac1-like
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA cers1-201 (1)    Ensembl 5875
Browsers: NCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM cers1 No data available
MARKER RELATIONSHIPS
cers1 Contained in: [BAC] DKEY-49M19 (1) (order this)
cers1 Encodes: [EST] fb75h07
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:XM_009295953 (1)
Genomic GenBank:BX649252 (1) 205949 nt Blast at MegaBLAST
Polypeptide UniProtKB:A0A0R4IS61 (1) 362 aa
Sequence Information (all 9)
ORTHOLOGY for cers1 ( Chr: 22 )
CITATIONS (17)