ZFIN ID: ZDB-GENE-050208-4
Gene Name: fetuin B
Gene Symbol: fetub    Nomenclature History

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Previous Name: im:6910148

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 22 Mapping Details/Browsers
Description: Predicted to have cysteine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. Predicted to localize to the extracellular region. Human ortholog(s) of this gene implicated in thrombophilia and thrombosis. Is expressed in liver and yolk syncytial layer. Orthologous to several human genes including FETUB (fetuin B).
Genome Resources: Alliance (1),  Gene:569489 (1),  Ensembl(GRCz11):ENSDARG00000053973 (2)
GENE EXPRESSION
All Expression Data: 8 figures from 2 publications
Directly Submitted Expression Data: 6 figures (12 images) from Thisse et al., 2004 [IMAGE:6910148]
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa24222 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37572 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH fetub HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH fetub VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process negative regulation of endopeptidase activity (more)
    Cellular Component extracellular space (more)
    Molecular Function cysteine-type endopeptidase inhibitor activity (more)
    GO Terms (all 5)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000010 Cystatin domain
    Conserved_site IPR001363 Proteinase inhibitor I25C, fetuin, conserved site
    Domain IPR025764 Fetuin-B-type cystatin domain
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM fetub No data available
    MARKER RELATIONSHIPS
    fetub Encodes: [EST] IMAGE:6910148 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_001922652 (1)
    Polypeptide UniProtKB:E7FE90 (1) 499 aa
    Sequence Information (all 6)
    ORTHOLOGY for fetub ( Chr: 22 )
    CITATIONS (19)