ZFIN ID: ZDB-GENE-050208-36
Gene Name: cyclin and CBS domain divalent metal cation transport mediator 2a
Gene Symbol: cnnm2a    Nomenclature History

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Previous Names: im:7136247, si:ch211-67n3.4

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Predicted to have magnesium ion transmembrane transporter activity. Involved in brain development and magnesium ion homeostasis. Predicted to localize to plasma membrane. Is expressed in several structures, including brain; digestive system; midbrain hindbrain boundary neural keel; pleuroperitoneal region; and scale. Used to study schizophrenia. Human ortholog(s) of this gene implicated in renal hypomagnesemia 6. Orthologous to human CNNM2 (cyclin and CBS domain divalent metal cation transport mediator 2).
Genome Resources: Alliance (1),  Gene:555472 (1),  Ensembl(GRCz11):ENSDARG00000061195 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
a357 Complex Unknown Unknown CRISPR
la027425Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa14149 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa22317 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-cnnm2a 1
    CRISPR2-cnnm2a 1
    CRISPR3-cnnm2a 1
    CRISPR4-cnnm2a 1
    MO1-cnnm2a N/A 1
    DISEASE ASSOCIATED WITH cnnm2a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    renal hypomagnesemia 6 Alliance Hypomagnesemia 6, renal 613882
    Hypomagnesemia, seizures, and mental retardation 616418
    DISEASE ASSOCIATED WITH cnnm2a VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    schizophrenia cnnm2aa357/a357 standard conditions Thyme et al., 2019
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process brain development (more)
    Cellular Component integral component of membrane (more)
    Molecular Function magnesium ion transmembrane transporter activity (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cnnm2a-201 (1)    Ensembl 2817
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cnnm2a No data available
    MARKER RELATIONSHIPS
    cnnm2a Contained in: [BAC] CH211-67N3 (1)
    cnnm2a Encodes: [EST] IMAGE:7136247 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001144785 (1) 2817 nt
    Genomic GenBank:AL928951 (1) 183050 nt
    Select Tool
    Polypeptide UniProtKB:A2ATX7 (1) 811 aa
    Sequence Information (all 7)
    ORTHOLOGY for cnnm2a ( Chr: 13 )
    CITATIONS (30)