ZFIN ID: ZDB-GENE-050208-244
Gene Name: phosphofurin acidic cluster sorting protein 1a
Gene Symbol: pacs1a    Nomenclature History

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Previous Names: pacs1, im:7146683, zgc:162891 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Predicted to have ion channel binding activity. Predicted to be involved in protein localization to plasma membrane. Human ortholog(s) of this gene implicated in Schuurs-Hoeijmakers Syndrome. Orthologous to human PACS1 (phosphofurin acidic cluster sorting protein 1).
Genome Resources: Alliance (1),  Gene:569034 (1),  Ensembl(GRCz11):ENSDARG00000044556 (1)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7146683]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la028337Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-pacs1a N/A 1
    PHENOTYPE
    Data: Fig. S4 from Fu et al., 2008
    Observed in:
    DISEASE ASSOCIATED WITH pacs1a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Schuurs-Hoeijmakers Syndrome Alliance Schuurs-Hoeijmakers syndrome 615009
    DISEASE ASSOCIATED WITH pacs1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process protein localization to plasma membrane (more)
    Molecular Function ion channel binding (more)
    GO Terms (all 2)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA pacs1a-201 (1)    Ensembl 3396
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM pacs1a No data available
    MARKER RELATIONSHIPS
    pacs1a Contained in: [BAC] CH211-196O14 (1), DKEYP-50D11 (1)
    pacs1a Encodes: [EST] IMAGE:7146683 (1)
    [cDNA] MGC:162891 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001098748 (1) 3415 nt
    Genomic GenBank:CR405687 (1) 96643 nt
    Select Tool
    Polypeptide UniProtKB:A5PKS9 (1) 909 aa
    Sequence Information (all 16)
    ORTHOLOGY for pacs1a ( Chr: 21 )
    CITATIONS (21)