ZFIN ID: ZDB-GENE-050208-22
Gene Name: sortilin-related receptor, L(DLR class) A repeats containing
Gene Symbol: sorl1    Nomenclature History

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Previous Name: im:7135957

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 15 Mapping Details/Browsers
Description: Predicted to be involved in post-Golgi vesicle-mediated transport; protein retention in Golgi apparatus; and protein targeting to lysosome. Predicted to localize to Golgi apparatus and integral component of membrane. Is expressed in central nervous system; hatching gland; mesoderm; and somite. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human SORL1 (sortilin related receptor 1).
Genome Resources: Alliance (1),  Gene:497306 (1),  Ensembl(GRCz11):ENSDARG00000013892 (2)
GENE EXPRESSION
All Expression Data: 7 figures from 2 publications
Directly Submitted Expression Data: 5 figures (8 images) from Thisse et al., 2004 [IMAGE:7135957]
Wild-type Stages, Structures: Segmentation:1-4 somites (10.33h-11.66h) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa774 Point Mutation Unknown Premature Stop ENU
sa1275 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa6373 Point Mutation Unknown Premature Stop ENU
    sa6374 Point Mutation Unknown Premature Stop ENU
    sa22633 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa32030 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa45536 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH sorl1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH sorl1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process post-Golgi vesicle-mediated transport (more)
    Cellular Component Golgi apparatus (more)
    Molecular Function molecular_function (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA sorl1-201 (1)    Ensembl 8581
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM sorl1 No data available
    MARKER RELATIONSHIPS
    sorl1 Contained in: [BAC] DKEY-40G16 (1) (order this), DKEY-182M1 (1) (order this)
    sorl1 Encodes: [EST] IMAGE:7135957 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_005157550 (1) 8536 nt
    Genomic GenBank:BX572648 (1) 180747 nt
    Select Tool
    Polypeptide UniProtKB:X1WHE3 (1) 2213 aa
    Sequence Information (all 10)
    ORTHOLOGY for sorl1 ( Chr: 15 )
    CITATIONS (21)