ZFIN ID: ZDB-GENE-050208-140
Gene Name: ALX homeobox 4b
Gene Symbol: alx4b    Nomenclature History

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Previous Names: im:7142878, si:ch73-220n21.1, zgc:162606 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 18 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in multicellular organism development and regulation of transcription by RNA polymerase II. Predicted to localize to nucleus. Is expressed in several structures, including brain; eye; optic vesicle; pharyngeal arch; and swim bladder bud. Human ortholog(s) of this gene implicated in craniosynostosis and parietal foramina. Orthologous to human ALX4 (ALX homeobox 4).
Genome Resources: Alliance (1),  Gene:497424 (1),  Ensembl(GRCz11):ENSDARG00000074442 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la027951Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la027952Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa36701 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH alx4b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    parietal foramina Alliance Parietal foramina 2 609597
    Frontonasal dysplasia 2 613451
    {Craniosynostosis 5, susceptibility to} 615529
    DISEASE ASSOCIATED WITH alx4b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process multicellular organism development (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA alx4b-202 (1)    Ensembl 2033
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM alx4b No data available
    MARKER RELATIONSHIPS
    alx4b Contained in: [BAC] CH73-220N21 (1)
    [Fosmid] CH1073-127O16 (1)
    alx4b Encodes: [EST] IMAGE:7142878 (1)
    [cDNA] MGC:162606 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001089357 (1) 2028 nt
    Genomic GenBank:CU929277 (1) 100482 nt
    Select Tool
    Polypeptide UniProtKB:A4IGC5 (1) 364 aa
    Sequence Information (all 17)
    ORTHOLOGY for alx4b ( Chr: 18 )
    CITATIONS (29)