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Gene

alx4b

ID
ZDB-GENE-050208-140
Name
ALX homeobox 4b
Symbol
alx4b Nomenclature History
Previous Names
  • im:7142878
  • si:ch73-220n21.1
  • zgc:162606 (1)
Type
protein_coding_gene
Location
Chr: 18 Mapping Details/Browsers
Description
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of transcription, DNA-templated. Predicted to be located in nucleus. Is expressed in several structures, including brain; eye; optic vesicle; pharyngeal arch; and swim bladder bud. Human ortholog(s) of this gene implicated in craniosynostosis and parietal foramina. Orthologous to human ALX4 (ALX homeobox 4).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
10 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With alx4b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
parietal foramina Alliance Parietal foramina 2 609597
Frontonasal dysplasia 2 613451
{Craniosynostosis 5, susceptibility to} 615529
Associated With alx4b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017970 Homeobox, conserved site
Domain IPR001356 Homeobox domain
Domain IPR003654 OAR domain
Family IPR033203 Homeobox protein aristaless-like 4
Homologous_superfamily IPR009057 Homeobox-like domain superfamily
Domain Details Per Protein
Protein Length Homeobox, conserved site Homeobox domain Homeobox-like domain superfamily Homeobox protein aristaless-like 4 OAR domain
UniProtKB:I3ITE6 363
UniProtKB:A4IGC5 364
UniProtKB:A0A2R8RTN2 259
UniProtKB:A0A0A0MPW6 265
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations