ZFIN ID: ZDB-GENE-050208-129
Gene Name: calcium channel, voltage-dependent, beta 2b
Gene Symbol: cacnb2b    Nomenclature History

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Previous Names: CAB2a (1), CACNB2.2 (1), cacnb2a (1), im:7141271, si:dkey-32m20.2

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Predicted to have high voltage-gated calcium channel activity. Predicted to be involved in chemical synaptic transmission; neuromuscular junction development; and regulation of voltage-gated calcium channel activity. Predicted to localize to voltage-gated calcium channel complex. Is expressed in several structures, including heart; integument; liver; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Brugada syndrome 4; hypertension; and hypertrophic cardiomyopathy. Orthologous to human CACNB2 (calcium voltage-gated channel auxiliary subunit beta 2).
Genome Resources: Alliance (1),  Gene:558806 (1),  Ensembl(GRCz11):ENSDARG00000055565 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
a247 Complex Unknown Unknown CRISPR
la014902Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la014903Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa10313 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa16129 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa31283 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR6-cacnb2b 1
    CRISPR7-cacnb2b 1
    CRISPR8-cacnb2b 1
    CRISPR9-cacnb2b 1
    DISEASE ASSOCIATED WITH cacnb2b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Brugada syndrome 4 Alliance Brugada syndrome 4 611876
    DISEASE ASSOCIATED WITH cacnb2b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process calcium ion transmembrane transport (more)
    Cellular Component integral component of membrane (more)
    Molecular Function voltage-gated calcium channel activity (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cacnb2b-203 (1)    Ensembl 1897
    ncRNA cacnb2b-002 (1)    Ensembl 702
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cacnb2b No data available
    MARKER RELATIONSHIPS
    cacnb2b Contained in: [BAC] CH211-106H4 (1), DKEY-32M20 (1) (order this)
    cacnb2b Encodes: [EST] IMAGE:7141271 (1)
    [cDNA] MGC:172001 (1), MGC:194397 (1), MGC:194433 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001166324 (1) 2136 nt
    Genomic GenBank:CR293515 (1) 192891 nt
    Select Tool
    Polypeptide UniProtKB:B2XY80 (1) 449 aa
    Sequence Information (all 30)
    ORTHOLOGY for cacnb2b ( Chr: 2 )
    CITATIONS (29)