ZFIN ID: ZDB-GENE-050204-3
Gene Name: glutaminase a
Gene Symbol: glsa    Nomenclature History

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Previous Name: glsl

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 22 Mapping Details/Browsers
Description: Predicted to have glutaminase activity. Predicted to be involved in glutamate biosynthetic process and glutamine catabolic process. Is expressed in brain; pectoral fin; and swim bladder. Human ortholog(s) of this gene implicated in early infantile epileptic encephalopathy. Orthologous to human GLS (glutaminase).
Genome Resources: Alliance (1),  Gene:564147 (1),  Ensembl(GRCz11):ENSDARG00000062812 (2)
GENE EXPRESSION
All Expression Data: 3 figures from 2 publications
Wild-type Stages, Structures: Larval:Protruding-mouth (72.0h-96.0h, 3.5mm) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS No data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH glsa HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Epileptic encephalopathy, early infantile, 71 618328
Global developmental delay, progressive ataxia, and elevated glutamine 618412
?Infantile cataract, skin abnormalities, glutamate excess, and impaired intellectual development 618339
DISEASE ASSOCIATED WITH glsa VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process glutamine metabolic process (more)
Molecular Function glutaminase activity (more)
GO Terms (all 4)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA glsa-201 (1)    Ensembl 977
glsa-202 (1)    Ensembl 1859
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM glsa No data available
MARKER RELATIONSHIPS
glsa Contained in: [BAC] DKEYP-84A8 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001045044 (1) 1859 nt
Genomic GenBank:BX548072 (1) 188936 nt
Select Tool
Polypeptide UniProtKB:Q1LWI2 (1) 591 aa
Sequence Information (all 15)
ORTHOLOGY for glsa ( Chr: 22 )
CITATIONS (27)