ZFIN ID: ZDB-GENE-050114-4
Gene Name: fms related receptor tyrosine kinase 3
Gene Symbol: flt3    Nomenclature History

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Previous Name: si:ch211-140b10.8

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 24 Mapping Details/Browsers
Description: Predicted to have transmembrane receptor protein tyrosine kinase activity. Involved in macrophage differentiation and myeloid cell development. Predicted to localize to the integral component of plasma membrane and receptor complex. Human ortholog(s) of this gene implicated in acute myeloid leukemia; precursor lymphoblastic lymphoma/leukemia; and prostate cancer. Is expressed in several structures, including ball; digestive system; hematopoietic system; kidney; and pericardial region. Orthologous to human FLT3 (fms related tyrosine kinase 3).
Genome Resources: Alliance (1),  Gene:566708 (1),  Ensembl(GRCz11):ENSDARG00000058503 (1)
DISEASE ASSOCIATED WITH flt3 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
acute lymphocytic leukemia Alliance Leukemia, acute lymphoblastic, somatic 613065
acute myeloid leukemia Alliance Leukemia, acute myeloid, reduced survival in, somatic 601626
Leukemia, acute myeloid, somatic 601626
DISEASE ASSOCIATED WITH flt3 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process macrophage differentiation (more)
Cellular Component integral component of membrane (more)
Molecular Function ATP binding (more)
GO Terms (all 26)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Domain IPR000719 Protein kinase domain
Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
Conserved_site IPR001824 Tyrosine-protein kinase, receptor class III, conserved site
Domain IPR003599 Immunoglobulin subtype
Domain IPR007110 Immunoglobulin-like domain
Active_site IPR008266 Tyrosine-protein kinase, active site
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR020635 Tyrosine-protein kinase, catalytic domain
Family IPR030118 Receptor-type tyrosine-protein kinase FLT3
Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA flt3-201 (1)    Ensembl 3849
Browsers: NCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM flt3 No data available
MARKER RELATIONSHIPS
flt3 Contained in: [BAC] CH211-140B10
flt3 Contains: [STS] zfishb-a511c07.q1c (1)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:XM_001921725 (1) 3840 bp
Genomic GenBank:BX571696 (1) 171175 bp
Select Tool
Polypeptide UniProtKB:E7F1P1 (1) 956 aa
Sequence Information (all 8)
ORTHOLOGY for flt3 ( Chr: 24 )
CITATIONS (22)