Gene

flt3

ID
ZDB-GENE-050114-4
Name
fms related receptor tyrosine kinase 3
Symbol
flt3 Nomenclature History
Previous Names
  • si:ch211-140b10.8
Type
protein_coding_gene
Location
Chr: 24 Mapping Details/Browsers
Description
Predicted to enable growth factor binding activity and transmembrane receptor protein tyrosine kinase activity. Acts upstream of or within macrophage differentiation and myeloid cell development. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be part of receptor complex. Predicted to be integral component of plasma membrane. Is expressed in several structures, including ball; digestive system; hematopoietic system; kidney; and pericardial region. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; acute myeloid leukemia; colorectal cancer; hepatocellular carcinoma; and prostate cancer. Orthologous to human FLT3 (fms related receptor tyrosine kinase 3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from He et al., 2014
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Peng et al., 2015
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With flt3 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
acute lymphoblastic leukemia Alliance Leukemia, acute lymphoblastic, somatic 613065
acute myeloid leukemia Alliance Leukemia, acute myeloid, reduced survival in, somatic 601626
acute myeloid leukemia Alliance Leukemia, acute myeloid, somatic 601626
Associated With flt3 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008266 Tyrosine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Conserved_site IPR001824 Tyrosine-protein kinase, receptor class III, conserved site
Domain IPR000719 Protein kinase domain
Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain IPR003599 Immunoglobulin subtype
Domain IPR007110 Immunoglobulin-like domain
Domain IPR020635 Tyrosine-protein kinase, catalytic domain
Family IPR030118 Receptor-type tyrosine-protein kinase FLT3
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
Domain Details Per Protein
Protein Length Immunoglobulin-like domain Immunoglobulin-like domain superfamily Immunoglobulin-like fold Immunoglobulin subtype Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Receptor-type tyrosine-protein kinase FLT3 Serine-threonine/tyrosine-protein kinase, catalytic domain Tyrosine-protein kinase, active site Tyrosine-protein kinase, catalytic domain Tyrosine-protein kinase, receptor class III, conserved site
UniProtKB:E7F1P1 956
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations