Gene
lmx1ba
- ID
- ZDB-GENE-050114-3
- Name
- LIM homeobox transcription factor 1, beta a
- Symbol
- lmx1ba Nomenclature History
- Previous Names
-
- lmx1b.2
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Is predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in neuron differentiation and regulation of transcription by RNA polymerase II. Acts upstream of or within animal organ development and glutamatergic neuron differentiation. Is expressed in several structures, including axis; midbrain hindbrain boundary neural rod; midbrain neural rod; nervous system; and periocular mesenchyme. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis and nail-patella syndrome. Orthologous to human LMX1B (LIM homeobox transcription factor 1 beta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
nail-patella syndrome | Alliance | Nail-patella syndrome | 161200 |
Focal segmental glomerulosclerosis 10 | 256020 |
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Length | Homeobox, conserved site | Homeobox domain | Homeobox-like domain superfamily | Zinc finger, LIM-type |
---|---|---|---|---|---|
UniProtKB:A0A0R4IL20
|
52 | ||||
UniProtKB:Q4VJ28
|
373 | ||||
UniProtKB:Q4L1M5
|
375 |
Type | Name | Length (nt) | Analysis |
---|---|---|---|
mRNA |
lmx1ba-202
(1)
|
185 nt |
Interactions and Pathways
No data available
Plasmids
No data available