ZFIN ID: ZDB-GENE-050114-2
Gene Name: LIM homeobox transcription factor 1, beta b
Gene Symbol: lmx1bb    Nomenclature History

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Previous Names: lmx1b.1, lmx1b (1), alo (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II regulatory region sequence-specific DNA binding activity. Involved in animal organ development and glutamatergic neuron differentiation. Predicted to localize to the nucleus. Human ortholog(s) of this gene implicated in nail-patella syndrome. Is expressed in several structures, including axis; midbrain hindbrain boundary neural keel; midbrain hindbrain boundary neural rod; nervous system; and otic vesicle. Orthologous to human LMX1B (LIM homeobox transcription factor 1 beta).
Genome Resources: Alliance (1),  Gene:554360 (1),  Ensembl(GRCz11):ENSDARG00000068365 (2)
DISEASE ASSOCIATED WITH lmx1bb HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
nail-patella syndrome Alliance Nail-patella syndrome 161200
DISEASE ASSOCIATED WITH lmx1bb VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process closure of optic fissure (more)
Cellular Component nucleus (more)
Molecular Function DNA binding (more)
GO Terms (all 21)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Conserved_site IPR017970 Homeobox, conserved site
Domain IPR001356 Homeobox domain
Domain IPR001781 Zinc finger, LIM-type
Homologous_superfamily IPR009057 Homeobox-like domain superfamily
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA lmx1bb-201 (1)    Ensembl 1952
ncRNA lmx1bb-002 (1)    Ensembl 697
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM lmx1bb
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg(-5.0lmx1bb:GFP) lmx1bb GFP Danio rerio 4 8
MARKER RELATIONSHIPS
lmx1bb Contained in: [BAC] CH211-81G2 (1), CH211-101A21 (1), DKEY-17A16 (1) (order this)
lmx1bb Encodes: [cDNA] MGC:194366 (1), MGC:194387 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001025167 (1) 1952 nt
Genomic GenBank:CR376762 (1) 183602 nt
Select Tool
Polypeptide UniProtKB:Q4L1M6 (1) 375 aa
Sequence Information (all 25)
ORTHOLOGY for lmx1bb ( Chr: 8 )
CITATIONS (48)