Gene

ezh1

ID

ZDB-GENE-050114-1

Name

enhancer of zeste 1 polycomb repressive complex 2 subunit

Symbol

ezh1 Nomenclature History

Previous Names

si:ch211-250i3.1
zgc:136829

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Predicted to enable chromatin binding activity and histone H3K27 methyltransferase activity. Predicted to be involved in heterochromatin formation. Predicted to act upstream of or within chromatin remodeling and methylation. Predicted to be part of ESC/E(Z) complex. Predicted to be active in nucleus. Is expressed in several structures, including blastomere; eye; gonad; gut; and pectoral fin bud. Orthologous to human EZH1 (enhancer of zeste 1 polycomb repressive complex 2 subunit).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

8 figures from 5 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Völkel et al., 2019
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ezh1 Human Ortholog

No data available

Associated With ezh1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001005	SANT/Myb domain
Domain	IPR001214	SET domain
Domain	IPR026489	CXC domain
Domain	IPR033467	Tesmin/TSO1-like CXC domain
Domain	IPR041343	Polycomb repressive complex 2 subunit EZH1/EZH2, tri-helical domain
Domain	IPR041355	Pre-SET CXC domain
Domain	IPR044438	EZH1, SET domain
Family	IPR021654	Histone-lysine N-methyltransferase EZH1/EZH2
Family	IPR045318	Histone-lysine N-methyltransferase EZH1/2-like
Homologous_superfamily	IPR046341	SET domain superfamily

Domain Details Per Protein

Protein	Length	CXC domain	EZH1, SET domain	Histone-lysine N-methyltransferase EZH1/2-like	Histone-lysine N-methyltransferase EZH1/EZH2	Polycomb repressive complex 2 subunit EZH1/EZH2, tri-helical domain	Pre-SET CXC domain	SANT/Myb domain	SET domain	SET domain superfamily	Tesmin/TSO1-like CXC domain
UniProtKB:E7FFB7 InterPro	756
UniProtKB:A0A8M2BBL7 InterPro	749

Transcripts

Genome Browsers

Type	Name	Length (nt)	Analysis
mRNA	ezh1-202 (1) Ensembl	1363 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	ezh1-203 (1) Ensembl	3711 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations