Gene

gnsa

ID
ZDB-GENE-050107-5
Name
glucosamine (N-acetyl)-6-sulfatase a
Symbol
gnsa Nomenclature History
Previous Names
  • gnsl
  • zgc:114066
Type
protein_coding_gene
Location
Chr: 4 Mapping Details/Browsers
Description
Predicted to have N-acetylglucosamine-6-sulfatase activity and glycosaminoglycan binding activity. Predicted to be involved in glycosaminoglycan metabolic process. Predicted to localize to lysosome. Human ortholog(s) of this gene implicated in mucopolysaccharidosis III and mucopolysaccharidosis type IIID. Orthologous to human GNS (glucosamine (N-acetyl)-6-sulfatase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With gnsa Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
mucopolysaccharidosis III Alliance Mucopolysaccharidosis type IIID 252940
mucopolysaccharidosis type IIID Alliance Mucopolysaccharidosis type IIID 252940
Associated With gnsa Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR024607 Sulfatase, conserved site
Domain IPR000917 Sulfatase, N-terminal
Family IPR012251 N-acetylglucosamine-6-sulfatase
Family IPR015981 N-acetylglucosamine-6-sulfatase, metazoan
Homologous_superfamily IPR017850 Alkaline-phosphatase-like, core domain superfamily
Domain Details Per Protein
Protein Length Alkaline-phosphatase-like, core domain superfamily N-acetylglucosamine-6-sulfatase N-acetylglucosamine-6-sulfatase, metazoan Sulfatase, conserved site Sulfatase, N-terminal
UniProtKB:Q4V902 538
UniProtKB:F1R152 549
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations