ZFIN ID: ZDB-GENE-050107-5
Gene Name: glucosamine (N-acetyl)-6-sulfatase a
Gene Symbol: gnsa    Nomenclature History

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Previous Names: gnsl, zgc:114066

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 4 Mapping Details/Browsers
Description: Predicted to have N-acetylglucosamine-6-sulfatase activity and glycosaminoglycan binding activity. Predicted to be involved in glycosaminoglycan metabolic process. Predicted to localize to lysosome. Human ortholog(s) of this gene implicated in mucopolysaccharidosis III and mucopolysaccharidosis type IIID. Orthologous to human GNS (glucosamine (N-acetyl)-6-sulfatase).
Genome Resources: Alliance (1),  Gene:566506 (1),  Ensembl(GRCz11):ENSDARG00000023766 (2)
GENE EXPRESSION
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa17618 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH gnsa HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    mucopolysaccharidosis III Alliance Mucopolysaccharidosis type IIID 252940
    mucopolysaccharidosis type IIID Alliance Mucopolysaccharidosis type IIID 252940
    DISEASE ASSOCIATED WITH gnsa VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process glycosaminoglycan metabolic process (more)
    Cellular Component lysosome (more)
    Molecular Function catalytic activity (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA gnsa-201 (1)    Ensembl 2660
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM gnsa No data available
    MARKER RELATIONSHIPS
    gnsa Contained in: [BAC] CH73-238H12 (1)
    gnsa Contains: [STS] z35723-a1498d05.q1c (1)
    gnsa Encodes: [cDNA] MGC:114066 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001030208 (1) 2646 nt
    Genomic GenBank:FP102892 (1) 95891 nt
    Select Tool
    Polypeptide UniProtKB:F1R152 (1) 549 aa
    Sequence Information (all 10)
    ORTHOLOGY for gnsa ( Chr: 4 )
    CITATIONS (23)