ZFIN ID: ZDB-GENE-050107-4
Gene Name: patatin-like phospholipase domain containing 6
Gene Symbol: pnpla6    Nomenclature History

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Previous Names: nte (1), wu:fy20f06

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Predicted to have lysophospholipase activity. Involved in anterior/posterior axis specification; axonogenesis; and negative regulation of BMP signaling pathway. Predicted to localize to endoplasmic reticulum. Human ortholog(s) of this gene implicated in Boucher-Neuhauser syndrome; Laurence-Moon syndrome; Oliver-McFarlane syndrome; and hereditary spastic paraplegia 39. Orthologous to human PNPLA6 (patatin like phospholipase domain containing 6).
Genome Resources: Alliance (1),  Gene:560986 (1),  Ensembl(GRCz11):ENSDARG00000010773 (2)
GENE EXPRESSION No data available
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la021234Tg Transgenic Insertion Unknown Unknown DNA
la028165Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa14069 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa17978 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa32741 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zko892a Small Deletion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • zko892b Small Deletion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-pnpla6 1
    MO1-pnpla6 N/A 2
    DISEASE ASSOCIATED WITH pnpla6 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Boucher-Neuhauser syndrome Alliance Boucher-Neuhauser syndrome 215470
    hereditary spastic paraplegia 39 Alliance Spastic paraplegia 39, autosomal recessive 612020
    Laurence-Moon syndrome Alliance ?Laurence-Moon syndrome 245800
    Oliver-McFarlane syndrome Alliance Oliver-McFarlane syndrome 275400
    DISEASE ASSOCIATED WITH pnpla6 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process anterior/posterior axis specification (more)
    Cellular Component endoplasmic reticulum (more)
    Molecular Function carboxylic ester hydrolase activity (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA pnpla6-201 (1)    Ensembl 771
    pnpla6-202 (1)    Ensembl 7644
    pnpla6-203 (1)    Ensembl 638
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM pnpla6 No data available
    MARKER RELATIONSHIPS
    pnpla6 Contained in: [BAC] CH211-254D18 (1)
    pnpla6 Contains: [STS] z35724-a2618a09.q1c (1)
    pnpla6 Encodes: [EST] fy20f06 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_005160052 (1) 7304 nt
    Genomic GenBank:BX901938 (1) 104059 nt
    Select Tool
    Polypeptide UniProtKB:F1R844 (1) 1342 aa
    Sequence Information (all 15)
    ORTHOLOGY for pnpla6 ( Chr: 1 )
    CITATIONS (26)