ZFIN ID: ZDB-GENE-050105-2
Gene Name: solute carrier family 6 member 5
Gene Symbol: slc6a5    Nomenclature History

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Previous Names: glyt2 (2), si:dkey-7n10.12

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have glycine:sodium symporter activity. Predicted to be involved in glycine import across plasma membrane and glycinergic synaptic transmission. Predicted to localize to the plasma membrane. Human ortholog(s) of this gene implicated in hyperekplexia 3. Is expressed in central nervous system and glycinergic neurons. Orthologous to human SLC6A5 (solute carrier family 6 member 5).
Genome Resources: Alliance (1),  Gene:494450 (1),  Ensembl(GRCz11):ENSDARG00000067964 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-slc6a5
1
CRISPR2-slc6a5 1
CRISPR3-slc6a5
1
PHENOTYPE No data available
DISEASE ASSOCIATED WITH slc6a5 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hyperekplexia 3 Alliance Hyperekplexia 3 614618
DISEASE ASSOCIATED WITH slc6a5 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process glycine import across plasma membrane (more)
Cellular Component integral component of membrane (more)
Molecular Function neurotransmitter:sodium symporter activity (more)
GO Terms (all 8)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Family IPR000175 Sodium:neurotransmitter symporter
Homologous_superfamily IPR037272 Sodium:neurotransmitter symporter superfamily
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA slc6a5-201 (1)    Ensembl 3118
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM slc6a5
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg(slc6a5:GFP) slc6a5 GFP Danio rerio 2 29
TgBAC(slc6a5:GAL4FF) slc6a5 GAL4FF Danio rerio 1 2
TgBAC(slc6a5:LOXP-mCherry-LOXP-GAL4FF) slc6a5 GAL4FFmCherry Danio rerio 1 4
TgBAC(slc6a5:LOXP-mCherry-LOXP-GFP) slc6a5 GFPmCherry Danio rerio 1 2
MARKER RELATIONSHIPS
slc6a5 Contained in: [BAC] CH211-262G18 (1), DKEY-7N10 (1) (order this)
slc6a5 Encodes: [cDNA] MGC:193549 (1)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_001009557 (1) 3025 bp
Genomic GenBank:AL954849 (1) 162939 bp
Select Tool
Polypeptide UniProtKB:A0A2R8QPW7 (1) 786 aa
Sequence Information (all 21)
ORTHOLOGY for slc6a5 ( Chr: 7 )
CITATIONS (47)