ZFIN ID: ZDB-GENE-050102-2
Gene Name: A-Raf proto-oncogene, serine/threonine kinase
Gene Symbol: araf
Sequence Ontology ID : SO:0000704

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Previous Names: sb:eu994, wu:fk45h07, zgc:92074

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(Including Attributions)
Location: Chr: 5 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Exhibits SMAD binding activity; involved in negative regulation of nodal signaling pathway and pathway-restricted SMAD protein phosphorylation; predicted to localize to the cytosol and mitochondrion;  ...
GENE EXPRESSION
All Expression Data: 3 figures from 3 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2005 [eu994]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Pharyngula:Prim-25 (36.0h-42.0h)
 
Curated Microarray Expression: GEO (1)
PHENOTYPE
Data: 5 figures from 2 publications
Observed in:
DISEASE ASSOCIATED WITH araf HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH araf VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process negative regulation of nodal signaling pathway (more)
Cellular Component cytosol (more)
Molecular Function SMAD binding (more)
GO Terms (all 22)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000719 (1)
  • InterPro:IPR001245 (1)
  • InterPro:IPR002219 (1)
  • InterPro:IPR003116 (1)
  • InterPro:IPR008271 (1)
  • InterPro:IPR011009 (1)
  • InterPro:IPR017441 (1)
  • InterPro:IPR020454 (1)
  • InterPro:IPR029071 (1)
  • PROSITE:PS00107 (1)
  • PROSITE:PS00108 (1)
  • PROSITE:PS00479 (1)
  • PROSITE:PS50011 (1)
  • PROSITE:PS50081 (1)
  • PROSITE:PS50898 (1)
  • Pfam:PF00130 (1)
  • Pfam:PF02196 (1)
  • Pfam:PF07714 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA araf-001 (1) 6809
    araf-002 (1) 6779
    araf-003 (1) 1210
    GENE PRODUCT DESCRIPTION No description available
    INTERACTIONS AND PATHWAYS
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM araf No data available
    MARKER RELATIONSHIPS
    arafContained in: [BAC] CH211-102C2 (1) (order this)
    arafEncodes: [EST] eu994 (1), fk45h07
    [cDNA] MGC:92074 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_205743 (1) 3488bp
    Genomic GenBank:CU041374 (1) 141040bp
    Select Tool
    Polypeptide UniProtKB:Q5FBD1 (1) 608aa
    Sequence Clusters UniGene:77625 (1)
    Sequence Information (all 48)
    OTHER araf GENE PAGES
  • Alliance (1)
  • Gene:403063 (1)
  • VEGA:OTTDARG00000026948 (1)
  • Ensembl(GRCz11):ENSDARG00000054533 (2)
  • ORTHOLOGY for araf (Chr: 5)
    CITATIONS (19)