Gene

araf

ID
ZDB-GENE-050102-2
Name
A-Raf proto-oncogene, serine/threonine kinase
Symbol
araf Nomenclature History
Previous Names
  • sb:eu994
  • wu:fk45h07
  • zgc:92074
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Exhibits SMAD binding activity. Involved in negative regulation of nodal signaling pathway and pathway-restricted SMAD protein phosphorylation. Predicted to localize to cytosol and mitochondrion. Is expressed in head. Orthologous to human ARAF (A-Raf proto-oncogene, serine/threonine kinase).
Genome Resources
Note
None
Expression
All Expression Data
3 figures from 3 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With araf Human Ortholog
No data available
Associated With araf Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
Domain IPR003116 Raf-like Ras-binding
Domain IPR020454 Diacylglycerol/phorbol-ester binding
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR029071 Ubiquitin-like domain superfamily
Domain Details Per Protein
Protein Length Diacylglycerol/phorbol-ester binding Protein kinase, ATP binding site Protein kinase C-like, phorbol ester/diacylglycerol-binding domain Protein kinase domain Protein kinase-like domain superfamily Raf-like Ras-binding Serine/threonine-protein kinase, active site Serine-threonine/tyrosine-protein kinase, catalytic domain Ubiquitin-like domain superfamily
UniProtKB:A0A0B4J1B1 265
UniProtKB:A0A0A1GUM7 76
UniProtKB:Q53WQ4 151
UniProtKB:A0A0A1GU50 604
UniProtKB:Q5M7Y2 604
UniProtKB:A0A0A1GVY9 329
UniProtKB:A0A0A1GRF4 469
UniProtKB:Q5FBD1 608
UniProtKB:F1QBH1 192
UniProtKB:Q75Y03 608
UniProtKB:Q75W79 607
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations