ZFIN ID: ZDB-GENE-050102-2
Gene Name: A-Raf proto-oncogene, serine/threonine kinase
Gene Symbol: araf
Previous Names: wu:fk45h07, zgc:92074
Location: Chr: 5   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: Fig. 1 from Liu et al., 2013
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Pharyngula:Prim-5 (24.0h-30.0h)
  whole organism
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Alleles: sa13556, sa20425
Knockdown reagents: MO1-araf (1), MO2-araf (1)
PHENOTYPE
Data: 4 figures from Liu et al., 2013
Observed in: hypoblast, margin, pathway-restricted SMAD protein phosphorylation, protein phosphorylation (all 6) expand
GENE ONTOLOGY
Ontology GO Term
Biological Process negative regulation of nodal signaling pathway (more)
Molecular Function SMAD binding (more)
GO Terms (all 16)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000719 (1)
  • InterPro:IPR001245 (1)
  • InterPro:IPR002219 (1)
  • InterPro:IPR003116 (1)
  • InterPro:IPR008271 (1)
  • InterPro:IPR011009 (1)
  • InterPro:IPR017441 (1)
  • InterPro:IPR020454 (1)
  • InterPro:IPR029071 (1)
  • PROSITE:PS00107 (1)
  • PROSITE:PS00108 (1)
  • PROSITE:PS00479 (1)
  • PROSITE:PS50011 (1)
  • PROSITE:PS50081 (1)
  • PROSITE:PS50898 (1)
  • Pfam:PF00130 (1)
  • Pfam:PF02196 (1)
  • Pfam:PF07714 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA araf-001 (1) 6809
    araf-002 (1) 6779
    araf-003 (1) 1210
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM araf No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    araf Contained in: [BAC] CH211-102C2 (1) (order this)
    araf Encodes: [EST] fk45h07
    [cDNA] MGC:92074 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_205743 (1) 3488 bp
    Genomic GenBank:CU041374 (1) 141040 bp
    Select Tool
    Polypeptide UniProtKB:Q5FBD1 (1) 608 aa
    Sequence Clusters UniGene:77625 (1)
    Sequence Information (all 29)
    OTHER araf GENE PAGES
  • Gene:403063 (1)
  • VEGA:OTTDARG00000026948 (1)
  • Ensembl(Zv9):ENSDARG00000054533 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA
    Zebrafish araf 5  
    Human ARAF X (Xp11.4-p11.2)
  • OMIM:311010
  • Gene:369
  • Orthology Details
    CITATIONS (13)