ZFIN ID: ZDB-GENE-050102-2
Gene Name: A-Raf proto-oncogene, serine/threonine kinase
Gene Symbol: araf
Previous Names: sb:eu994, wu:fk45h07, zgc:92074
Location: Chr: 5 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2005 [eu994]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Pharyngula:Prim-5 (24.0h-30.0h)
  whole organism
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS 
Allele Type Mutagen Suppliers
sa13556 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa20425 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Targeting reagents: MO1-araf (1), MO2-araf (1)
    PHENOTYPE
    Data: 4 figures from Liu et al., 2013
    Observed in: hypoblast, margin, pathway-restricted SMAD protein phosphorylation, protein phosphorylation (all 6) expand
    DISEASE ASSOCIATED WITH araf HUMAN ORTHOLOG No data available
    GENE ONTOLOGY 
    Ontology GO Term
    Biological Process negative regulation of nodal signaling pathway (more)
    Molecular Function SMAD binding (more)
    GO Terms (all 16)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000719 (1)
  • InterPro:IPR001245 (1)
  • InterPro:IPR002219 (1)
  • InterPro:IPR002290 (1)
  • InterPro:IPR003116 (1)
  • InterPro:IPR008271 (1)
  • InterPro:IPR011009 (1)
  • InterPro:IPR017441 (1)
  • InterPro:IPR020454 (1)
  • InterPro:IPR029071 (1)
  • PROSITE:PS00107 (1)
  • PROSITE:PS00108 (1)
  • PROSITE:PS00479 (1)
  • PROSITE:PS50011 (1)
  • PROSITE:PS50081 (1)
  • PROSITE:PS50898 (1)
  • Pfam:PF00130 (1)
  • Pfam:PF02196 (1)
  • Pfam:PF07714 (1)
  • EC:2.7.11.13 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA araf-001 (1) 6809
    araf-002 (1) 6779
    araf-003 (1) 1210
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM araf No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS 
    arafContained in: [BAC] CH211-102C2 (1) (order this)
    arafEncodes: [EST] eu994 (1), fk45h07
    [cDNA] MGC:92074 (1) (order this)
    SEQUENCE INFORMATION 
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_205743 (1) 3488bp
    Genomic GenBank:CU041374 (1) 141040bp
    Select Tool
    Polypeptide UniProtKB:Q5FBD1 (1) 608aa
    Sequence Clusters UniGene:77625 (1)
    Sequence Information (all 35)
    OTHER araf GENE PAGES 
  • Gene:403063 (1)
  • VEGA:OTTDARG00000026948 (1)
  • Ensembl(GRCz10):ENSDARG00000054533 (1)
  • ORTHOLOGY for araf (Chr: 5) 
    Species Symbol Chromosome Accession # Evidence
    Human ARAF X
  • Gene:369
  • OMIM:311010
  • HGNC:646
  • Amino acid sequence comparison (1)
    Download Curated Orthology
    CITATIONS (16)