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ZIRC
ZFIN ID: ZDB-GENE-041220-1
Gene Name: transferrin receptor 1a
Gene Symbol: tfr1a    Nomenclature History

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Previous Names: chianti, cia

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Predicted to have transferrin receptor activity. Involved in cellular iron ion homeostasis; hemoglobin biosynthetic process; and hemopoiesis. Predicted to localize to the external side of plasma membrane. Human ortholog(s) of this gene implicated in breast carcinoma; multiple myeloma; ovarian cancer; and primary immunodeficiency disease. Is expressed in blood; blood island; intermediate cell mass of mesoderm; presumptive blood; and ventral mesoderm. Orthologous to human TFRC (transferrin receptor).
Genome Resources: Alliance (1),  Gene:494477 (1),  Ensembl(GRCz11):ENSDARG00000101322 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la028827Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa1799 Point Mutation Unknown Missense ENU
    t20824 Point Mutation Unknown Missense ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • t25302 Point Mutation Unknown Missense ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tp327 Point Mutation Unknown Missense ENU
    tu25f Point Mutation Donor Splice Site Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-tfr1a N/A 2
    MO2-tfr1a N/A 1
    DISEASE ASSOCIATED WITH tfr1a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Immunodeficiency 46 616740
    DISEASE ASSOCIATED WITH tfr1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cellular iron ion homeostasis (more)
    Cellular Component integral component of membrane (more)
    Molecular Function transferrin receptor activity (more)
    GO Terms (all 12)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA tfr1a-201 (1)    Ensembl 2914
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tfr1a No data available
    MARKER RELATIONSHIPS
    tfr1a Contained in: [BAC] CH73-329G8 (1) (order this), CH211-162E15 (1) (order this)
    tfr1a Encodes: [cDNA] MGC:194146 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001009917 (1) 2313 bp
    Genomic GenBank:CU929154 (1) 85598 bp
    Select Tool
    Polypeptide UniProtKB:B3DHD1 (1) 770 aa
    Sequence Clusters UniGene:87179 (1)
    Sequence Information (all 16)
    ORTHOLOGY for tfr1a ( Chr: 2 )
    CITATIONS (41)