ZFIN ID: ZDB-GENE-041219-2
Gene Name: ADP-ribosylation factor-like 6
Gene Symbol: arl6    Nomenclature History

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Previous Names: bbs3 (1), zgc:101762

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Predicted to have GTP binding activity. Involved in several processes, including Kupffer's vesicle development; melanosome transport; and regulation of Notch signaling pathway. Predicted to localize to the axoneme. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome; Bardet-Biedl syndrome 1; Bardet-Biedl syndrome 3; and retinitis pigmentosa 55. Is expressed in adipose tissue; brain; eye; heart; and retina. Orthologous to human ARL6 (ADP ribosylation factor like GTPase 6).
Genome Resources: Alliance (1),  Gene:494134 (1),  Ensembl(GRCz11):ENSDARG00000032056 (1)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:101762]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la021136Tg Transgenic Insertion Unknown Unknown DNA
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-arl6 N/A 3
MO2-arl6 N/A 1
MO3-arl6 N/A 1
MO4-arl6 N/A 3
DISEASE ASSOCIATED WITH arl6 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Bardet-Biedl syndrome 1 Alliance {Bardet-Biedl syndrome 1, modifier of} 209900
Bardet-Biedl syndrome 3 Alliance Bardet-Biedl syndrome 3 600151
retinitis pigmentosa 55 Alliance ?Retinitis pigmentosa 55 613575
DISEASE ASSOCIATED WITH arl6 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process determination of left/right symmetry (more)
Cellular Component cell projection (more)
Molecular Function GTPase activity (more)
GO Terms (all 24)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Domain IPR005225 Small GTP-binding protein domain
Family IPR006689 Small GTPase superfamily, ARF/SAR type
Family IPR041839 ADP-ribosylation factor-like protein 6
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA arl6-201 (1)    Ensembl 2372
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM arl6 No data available
MARKER RELATIONSHIPS
arl6 Contained in: [BAC] DKEY-24H22 (1) (order this)
arl6 Encodes: [cDNA] MGC:101762 (1), MGC:192312 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001008733 (1) 1188 nt
Genomic GenBank:BX901972 (1) 212798 nt Blast at MegaBLAST
Polypeptide UniProtKB:B2GRI2 (1) 186 aa
Sequence Information (all 16)
ORTHOLOGY for arl6 ( Chr: 1 )
CITATIONS (28)