ZFIN ID: ZDB-GENE-041212-73
Gene Name: 24-dehydrocholesterol reductase
Gene Symbol: dhcr24    Nomenclature History

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Previous Name: zgc:101638

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Predicted to have delta24(24-1) sterol reductase activity. Predicted to be involved in steroid metabolic process. Predicted to localize to the cytoplasm and membrane. Human ortholog(s) of this gene implicated in lipid metabolism disorder. Is expressed in cranial ganglion; lens; solid lens vesicle; telencephalon; and yolk syncytial layer. Orthologous to human DHCR24 (24-dehydrocholesterol reductase).
Genome Resources: Alliance (1),  Gene:494102 (1),  Ensembl(GRCz11):ENSDARG00000013236 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la013955Tg Transgenic Insertion Unknown Unknown DNA
la021775Tg Transgenic Insertion Unknown Unknown DNA
sa3089 Point Mutation Unknown Premature Stop ENU
sa5668 Point Mutation Unknown Premature Stop ENU
sa15847 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH dhcr24 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Desmosterolosis 602398
    DISEASE ASSOCIATED WITH dhcr24 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process oxidation-reduction process (more)
    Cellular Component integral component of membrane (more)
    Molecular Function FAD binding (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR006094 FAD linked oxidase, N-terminal
    Domain IPR016166 FAD-binding domain, PCMH-type
    Homologous_superfamily IPR016169 FAD-binding, type PCMH, subdomain 2
    Homologous_superfamily IPR036318 FAD-binding, type PCMH-like superfamily
    Family IPR040165 Delta(24)-sterol reductase
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA dhcr24-201 (1)    Ensembl 1286
    dhcr24-202 (1)    Ensembl 1828
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM dhcr24 No data available
    MARKER RELATIONSHIPS
    dhcr24 Contained in: [BAC] CH211-121A2 (1), DKEYP-51F12 (1)
    dhcr24 Encodes: [EST] IMAGE:7220762
    [cDNA] MGC:101638 (1), MGC:173744 (1), MGC:193073 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001008645 (1) 1849 bp
    Genomic GenBank:BX323071 (1) 208118 bp Blast at MegaBLAST
    Polypeptide UniProtKB:F1QUM4 (1) 516 aa
    Sequence Information (all 20)
    ORTHOLOGY for dhcr24 ( Chr: 20 )
    CITATIONS (29)