Gene

mgme1

ID
ZDB-GENE-041212-68
Name
mitochondrial genome maintenance exonuclease 1
Symbol
mgme1 Nomenclature History
Previous Names
  • im:7154190
  • zgc:101650
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Predicted to enable single-stranded DNA exodeoxyribonuclease activity. Predicted to be involved in mitochondrial DNA replication. Predicted to act upstream of or within mitochondrial DNA repair. Predicted to be active in mitochondrion. Is expressed in several structures, including digestive system; lens; solid lens vesicle; vasculature; and ventral mesoderm. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 11. Orthologous to human MGME1 (mitochondrial genome maintenance exonuclease 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
5 figures from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With mgme1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
mitochondrial DNA depletion syndrome 11 Alliance Mitochondrial DNA depletion syndrome 11 615084
Associated With mgme1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR038726 PD-(D/E)XK endonuclease-like domain, AddAB-type
Homologous_superfamily IPR011335 Restriction endonuclease type II-like
Homologous_superfamily IPR011604 PD-(D/E)XK endonuclease-like domain superfamily
Domain Details Per Protein
Protein Length PD-(D/E)XK endonuclease-like domain, AddAB-type PD-(D/E)XK endonuclease-like domain superfamily Restriction endonuclease type II-like
UniProtKB:Q5PRC4 334
UniProtKB:B8A4D5 334
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations