Gene

arhgef7b

ID
ZDB-GENE-041212-49
Name
Rho guanine nucleotide exchange factor (GEF) 7b
Symbol
arhgef7b Nomenclature History
Previous Names
  • arhgef7
  • bbh (1)
  • bpix (1)
  • im:7142367
  • wu:fc35h08
  • zgc:101775
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Predicted to have guanyl-nucleotide exchange factor activity. Involved in several processes, including endothelial cell proliferation; epiboly involved in gastrulation with mouth forming second; and protein localization to adherens junction. Predicted to localize to lamellipodium. Is expressed in several structures, including EVL; axial vasculature; hatching gland; nervous system; and periderm. Used to study cerebrovascular disease. Orthologous to human ARHGEF7 (Rho guanine nucleotide exchange factor 7).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
9 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
27 figures from 9 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With arhgef7b Human Ortholog
No data available
Associated With arhgef7b Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved site
Domain IPR000219 Dbl homology (DH) domain
Domain IPR001452 SH3 domain
Domain IPR001715 Calponin homology domain
Domain IPR001849 Pleckstrin homology domain
Domain IPR032409 Rho guanine nucleotide exchange factor, coiled-coil domain
Homologous_superfamily IPR011993 PH-like domain superfamily
Homologous_superfamily IPR035899 Dbl homology (DH) domain superfamily
Homologous_superfamily IPR036028 SH3-like domain superfamily
Homologous_superfamily IPR036872 CH domain superfamily
Domain Details Per Protein
Protein Length Calponin homology domain CH domain superfamily Dbl homology (DH) domain Dbl homology (DH) domain superfamily Guanine-nucleotide dissociation stimulator, CDC24, conserved site PH-like domain superfamily Pleckstrin homology domain Rho guanine nucleotide exchange factor, coiled-coil domain SH3 domain SH3-like domain superfamily
UniProtKB:F1RE63 799
UniProtKB:F1QA07 643
UniProtKB:Q5PRA8 799
UniProtKB:A5X7A1 643
UniProtKB:A5X7A2 799
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations