ZFIN ID: ZDB-GENE-041210-77
Gene Name: adenosine deaminase 2b
Gene Symbol: ada2b    Nomenclature History

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Previous Names: ADA2-2 (1), cecr1b, si:ch211-214j24.5

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 4 Mapping Details/Browsers
Description: Predicted to have adenosine deaminase activity. Involved in blood vessel endothelial cell differentiation and neutrophil differentiation. Predicted to localize to extracellular space. Is expressed in several structures, including cardiovascular system; gill; liver; notochord; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Sneddon syndrome. Orthologous to human ADA2 (adenosine deaminase 2).
Genome Resources: Alliance (1),  Gene:559295 (1),  Ensembl(GRCz11):ENSDARG00000015623 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-ada2b N/A 2
MO2-ada2b N/A 1
PHENOTYPE
Data: 3 figures from 2 publications
Observed in:
DISEASE ASSOCIATED WITH ada2b HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Sneddon syndrome Alliance ?Sneddon syndrome 182410
Vasculitis, autoinflammation, immunodeficiency, and hematologic defects syndrome 615688
DISEASE ASSOCIATED WITH ada2b VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process blood vessel endothelial cell differentiation (more)
Cellular Component extracellular space (more)
Molecular Function adenosine deaminase activity (more)
GO Terms (all 7)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA ada2b-201 (1)    Ensembl 2228
Browsers: NCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM ada2b No data available
MARKER RELATIONSHIPS
ada2b Contained in: [BAC] CH211-214J24 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:XM_682627 (1)
Genomic GenBank:BX323558 (1) 160379 nt
Select Tool
Polypeptide UniProtKB:F6NKG5 (1) 501 aa
Sequence Information (all 7)
ORTHOLOGY for ada2b ( Chr: 4 )
CITATIONS (30)