Gene

shank3b

ID
ZDB-GENE-041210-74
Name
SH3 and multiple ankyrin repeat domains 3b
Symbol
shank3b Nomenclature History
Previous Names
  • si:dkey-153k10.1
  • zs3.1 (1)
Type
protein_coding_gene
Location
Chr: 4 Mapping Details/Browsers
Description
Predicted to enable ionotropic glutamate receptor binding activity and synaptic receptor adaptor activity. Acts upstream of or within intestinal motility. Predicted to be located in cytoplasm and synapse. Predicted to be active in dendritic spine and postsynaptic density. Predicted to colocalize with postsynaptic membrane. Is expressed in brain; forebrain; and midbrain. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in Phelan-McDermid syndrome and schizophrenia 15. Orthologous to human SHANK3 (SH3 and multiple ankyrin repeat domains 3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
4 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
8 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With shank3b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Phelan-McDermid syndrome Alliance Phelan-McDermid syndrome 606232
schizophrenia 15 Alliance {Schizophrenia 15} 613950
Associated With shank3b Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001452 SH3 domain
Domain IPR001478 PDZ domain
Domain IPR001660 Sterile alpha motif domain
Domain IPR041489 PDZ domain 6
Homologous_superfamily IPR013761 Sterile alpha motif/pointed domain superfamily
Homologous_superfamily IPR036028 SH3-like domain superfamily
Homologous_superfamily IPR036034 PDZ superfamily
Homologous_superfamily IPR036770 Ankyrin repeat-containing domain superfamily
Repeat IPR002110 Ankyrin repeat
Domain Details Per Protein
Protein Length Ankyrin repeat Ankyrin repeat-containing domain superfamily PDZ domain PDZ domain 6 PDZ superfamily SH3 domain SH3-like domain superfamily Sterile alpha motif domain Sterile alpha motif/pointed domain superfamily
UniProtKB:A0A2R8QHB0 1538
UniProtKB:H0WEB5 103
UniProtKB:F1R0Q7 1631
UniProtKB:A0A2R8PWB0 1517
UniProtKB:F1Q560 1603
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations