ZFIN ID: ZDB-GENE-041210-343
Gene Name: IQ motif and Sec7 domain ArfGEF 3a
Gene Symbol: iqsec3a    Nomenclature History

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Previous Name: si:ch211-15l13.1 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 4 Mapping Details/Browsers
Description: Predicted to have ARF guanyl-nucleotide exchange factor activity. Predicted to be involved in actin cytoskeleton organization. Is expressed in central nervous system and neurons. Orthologous to human IQSEC3 (IQ motif and Sec7 domain ArfGEF 3).
Genome Resources: Alliance (1),  Gene:797355 (1),  Ensembl(GRCz11):ENSDARG00000099850 (1)
GENE EXPRESSION
Directly Submitted Expression Data: 4 figures (3 images) from Thisse et al., 2004 [IMAGE:7141416]
Wild-type Stages, Structures: Segmentation:20-25 somites (19.0h-22.0h) to Hatching:Long-pec (48.0h-60.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa6950 Point Mutation Unknown Premature Stop ENU
sa30852 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa31400 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH iqsec3a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH iqsec3a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of ARF protein signal transduction (more)
    Molecular Function ARF guanyl-nucleotide exchange factor activity (more)
    GO Terms (all 3)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA iqsec3a-201 (1)    Ensembl 5161
    ncRNA ottdart00000061758 (1)    Ensembl 1133
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM iqsec3a No data available
    MARKER RELATIONSHIPS
    iqsec3a Contained in: [BAC] CH211-15L13 (1), CH211-224C7 (1), DKEY-28G6 (1) (order this), DKEY-193G4 (1) (order this), DKEYP-63F6 (1)
    iqsec3a Encodes: [EST] IMAGE:7141416 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_009300450 (1)
    Genomic GenBank:CU137645 (1) 292984 nt Blast at MegaBLAST
    Polypeptide UniProtKB:A0A0R4IUT7 (1) 1277 aa
    Sequence Information (all 39)
    ORTHOLOGY for iqsec3a ( Chr: 4 )
    CITATIONS (17)