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ZIRC
ZFIN ID: ZDB-GENE-041210-23
Gene Name: phosphodiesterase 3A, cGMP-inhibited
Gene Symbol: pde3a    Nomenclature History

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Previous Name: si:dkey-48h7.2

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 4 Mapping Details/Browsers
Description: Predicted to have 3',5'-cyclic-AMP phosphodiesterase activity. Predicted to be involved in several processes, including cyclic-nucleotide-mediated signaling; oocyte maturation; and positive regulation of oocyte development. Predicted to localize to the cytosol. Human ortholog(s) of this gene implicated in hypertension and brachydactyly syndrome. Is expressed in oocyte and oocyte stage V. Orthologous to human PDE3A (phosphodiesterase 3A).
Genome Resources: Alliance (1),  Gene:567051 (1),  Ensembl(GRCz11):ENSDARG00000004227 (2)
GENE EXPRESSION
All Expression Data: Fig. 1 from Pang et al., 2018
Wild-type Stages, Structures: Adult (90d-730d, breeding adult) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS No data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH pde3a HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hypertension and brachydactyly syndrome Alliance Hypertension and brachydactyly syndrome 112410
DISEASE ASSOCIATED WITH pde3a VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process signal transduction (more)
Cellular Component integral component of membrane (more)
Molecular Function 3',5'-cyclic-nucleotide phosphodiesterase activity (more)
GO Terms (all 14)
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA pde3a-201 (1)    Ensembl 4005
Browsers: NCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM pde3a
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
tg(hse:pde3a,hse:gfp) HSE GFPpde3a Danio rerio 1 1
MARKER RELATIONSHIPS
pde3a Contained in: [BAC] DKEY-48H7 (1) (order this)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:XM_009299994 (1)
Genomic GenBank:BX323818 (1) 196712 bp
Select Tool
Polypeptide UniProtKB:F6P4K3 (1) 1117 aa
Sequence Information (all 14)
ORTHOLOGY for pde3a ( Chr: 4 )
CITATIONS (17)